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Although no tumor factors have been validated for use as preoperative prognostic markers of endometrial cancer at yet, human epididymis protein 4 (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4) has received much interest as a potential diagnostic and prognostic tumor marker. Since 2008, several studies have explored its utility in the management of endometrial cancer: <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4 may be a useful preoperative prognostic marker because it is associated with lymphatic metastasis and other unfavorable factors in endometrial cancer. In addition, some studies have explored a <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4 cutoff value to classify patients according to lymph node involvement. <jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>4 might be beneficial as a serum marker that helps clinicians in the decision\u2010making algorithm for treatment of endometrial cancer, enabling them to perform individualized operations and decrease the adverse effects of unnecessary surgery.<\/jats:p>","DOI":"10.1002\/ijgo.13140","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T08:06:51Z","timestamp":1583741211000},"page":"265-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>HE<\/scp>4 tumor marker as a predictive factor for lymphatic metastasis in endometrial cancer"],"prefix":"10.1002","volume":"149","author":[{"given":"Andrea","family":"Espiau Romera","sequence":"first","affiliation":[{"name":"Department of Gynecology Miguel Servet University Hospital  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Cuesta Guardiola","sequence":"additional","affiliation":[{"name":"Department of Gynecology University Hospital of Le\u00f3n  Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Benito Vielba","sequence":"additional","affiliation":[{"name":"Department of Gynecology Miguel Servet University Hospital  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"De Bonrostro Torralba","sequence":"additional","affiliation":[{"name":"Department of Gynecology Miguel Servet University Hospital  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pluvio J.","family":"Coronado Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Gynecology San Carlos Clinic Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Baquedano Mainar","sequence":"additional","affiliation":[{"name":"Department of Gynecology Miguel Servet University Hospital  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-43139-0_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod45.2.350"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2017.1282824"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606092"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2017.1266263"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428318757103"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0757"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000609"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.10.036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.318"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3049-3"},{"key":"e_1_2_7_15_1","first-page":"1185","article-title":"Utility of Tumor Marker HE4 to predict depth of myometrial invasion in endometrioid adenocarcinoma of the uterus","volume":"21","author":"Moore RG","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.109"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05276-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12235"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1190-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61766-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.3.1489"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2015.07.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.10.025"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0583-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.04.014"}],"container-title":["International Journal of Gynecology &amp; 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