{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:44:30Z","timestamp":1770745470934,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of adjunctive use of vaginal progesterone after McDonald cerclage on the rate of second\u2010trimester abortion in singleton pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled trial at Woman's Health Hospital, Assiut University, Egypt, between April 2017 and March 2019 enrolled women eligible for McDonald cerclage. After cerclage, participants were randomly assigned to receive progesterone (400\u00a0mg pessary) once daily until 37\u00a0weeks or no progesterone. The primary outcome was rate of abortion before 28\u00a0weeks. Secondary outcomes included gestational age at delivery, preterm delivery, mean birthweight, Apgar score, and admission to the neonatal intensive care unit (<jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of spontaneous abortion was higher in the no\u2010progesterone group (<jats:italic>P<\/jats:italic>=0.016). Mean gestational age and mean birthweight was higher in the progesterone group (<jats:italic>P<\/jats:italic>&lt;0.001 and <jats:italic>P<\/jats:italic>=0.002, respectively). The frequency of preterm neonates, neonates with Apgar score less than 7, and admission to <jats:styled-content style=\"fixed-case\">NICU<\/jats:styled-content> was higher in the progesterone group than in the no\u2010progesterone group (<jats:italic>P<\/jats:italic>=0.005, <jats:italic>P<\/jats:italic>=0.008, and <jats:italic>P<\/jats:italic>=0.044, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjunctive use of vaginal progesterone after McDonald cerclage was found to decrease the frequency of second\u2010trimester abortion and to improve perinatal outcomes in singleton pregnancy.<\/jats:p><jats:p><jats:bold>Clinicaltrials.gov: <\/jats:bold><jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02846909.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13148","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T13:56:52Z","timestamp":1586008612000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<i>Retracted:<\/i> Effect of adjunctive vaginal progesterone after McDonald cerclage on the rate of second\u2010trimester abortion in singleton pregnancy: a randomized controlled trial"],"prefix":"10.1002","volume":"149","author":[{"given":"Mohammed K.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh E.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal H.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esraa Y.","family":"Badran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.04.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5138"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.12.003"},{"key":"e_1_2_7_5_1","first-page":"43","article-title":"Clinical outcome of therapeutic cervical cerclage in short cervix syndrome","volume":"53","author":"Wang HL","year":"2018","journal-title":"Zhonghua Fu Chan KeZaZhi"},{"key":"e_1_2_7_6_1","first-page":"CD008991","article-title":"Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy","volume":"6","author":"Alfirevic Z","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1140139"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4315-y"},{"key":"e_1_2_7_9_1","unstructured":"Royal College of Obstetrician and Gynecologists (RCOG).Cervical Cerclage. 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