{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:10:12Z","timestamp":1780549812963,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate differences in Doppler parameters and pregnancy outcomes, if any, and to determine the predictive accuracy of such indices, as well as the effects of low\u2010dose aspirin (LDA) in unexplained recurrent pregnancy loss (URPL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational study was conducted at Ren Ji Hospital, Shanghai, China, from May 2015 to December 2016. The endometrial thickness, and the pulsatility index (PI), resistive index (RI), and systolic\u2010to\u2010diastolic ratio (S\/D) values of endometrial and uterine artery blood flow were collected. Receiver operating characteristic (ROC) curve analysis was used to analyze data from URPL patients (three or more first\u2010trimester spontaneous abortions with unknown etiology) and patients with normal fertility. A second ultrasonography examination was performed in URPL patients who had received daily LDA for 2\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 190 URPL patients and 35 control patients. Endometrial thickness was significantly thinner in URPL patients than control patients (<jats:italic>P<\/jats:italic>=0.005). The PI, RI, and S\/D values for endometrial blood flow and the mean PI, RI, and S\/D values for uterine arteries were significantly higher in URPL patients (<jats:italic>P<\/jats:italic>&lt;0.001). The predictive accuracy of the indices mentioned above were 0.660, 0.802, 0.852, 0.837, 0.784, 0.929, and 0.929, respectively. Following LDA supplementation, URPL patients showed a significant reduction in resistance to endometrial and uterine artery blood flow (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>URPL patients had impaired uterine perfusion. Doppler parameters are valuable in predicting women at high risk of URPL. LDA could be effective in improving endometrial receptivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13160","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T10:20:18Z","timestamp":1586946018000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Low\u2010dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss"],"prefix":"10.1002","volume":"150","author":[{"given":"Tongfei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Obstetrics and Gynecology Department of Concord Hospital of the Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangsun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_8_3_1","unstructured":"Group EPGD.Guideline of the European Society of Human Reproduction and Embryology.2017."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(91)90138-B"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7251.1708"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"CD004734","article-title":"Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome","author":"Kaandorp S","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","unstructured":"Gynaecologists RCoOa.The investigation and treatment of couples with recurrent first\u2010trimester and second\u2010trimester miscarriage. 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