{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:11:57Z","timestamp":1773115917474,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Hospital Universitario Mayor M\u00e9deri - Universidad del Rosario"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the association between increased levels of D\u2010dimer and severity of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested, prospective cohort, analytical case\u2013control study was conducted among women with pre\u2010eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18\u00a0years, gestational age of more than 20\u00a0weeks, a single pregnancy with a living fetus, and a diagnosis of pre\u2010eclampsia. D\u2010dimer was measured by immunoturbidimetry at the time of diagnosis of pre\u2010eclampsia, applying cut\u2010off points adjusted for gestational age. Statistical analysis involved unconditional logistic regression for the association of elevated D\u2010dimer with severe pre\u2010eclampsia adjusted by confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 132 patients with pre\u2010eclampsia, of which 44 were classed as controls and 88 were classed as having severe pre\u2010eclampsia (case group). Cohort characteristics included: age between 18 and 45\u00a0years (mean 28.0\u00a0\u00b1\u00a06.3\u00a0years); presence of gestational hypertension (10.6%), chronic arterial hypertension (9.0%); and gestational diabetes (5.3%). In the case group, levels of D\u2010dimer were significantly higher than in controls (19.3% vs 2.3%, odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 10.30, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1.32\u201380.14, <jats:italic>P<\/jats:italic>=0.004) as well as significant in the unconditional logistic regression model adjusted for maternal age, parity, gestational age, and comorbidities (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10.02, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.28\u201378.68, <jats:italic>P<\/jats:italic>=0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated levels of D\u2010dimer and severe pre\u2010eclampsia are strongly associated, reinforcing evidence that one of the physiopathologic bases of the condition is the activation of fibrinolysis and the coagulation system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13163","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T18:09:58Z","timestamp":1586801398000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elevated levels of D\u2010dimer tested by immunoturbidimetry are associated with the extent of severity of pre\u2010eclampsia"],"prefix":"10.1002","volume":"150","author":[{"given":"Yolima","family":"Rodr\u00edguez\u2010Pe\u00f1a","sequence":"first","affiliation":[{"name":"Department of Sexual and Reproductive Health Hospital Universitario Mayor M\u00e9deri Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milc\u00edades","family":"Ib\u00e1\u00f1ez\u2010Pinilla","sequence":"additional","affiliation":[{"name":"M\u00e9deri Research Center Universitario Mayor M\u00e9deri Hospital Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.09.050"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.02.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114488"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.01.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029607299986"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.545432"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165845"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.143278"},{"key":"e_1_2_9_10_1","first-page":"437","article-title":"Elevation in D\u2010dimer concentrations is positively correlated with gestation in normal uncomplicated pregnancy","volume":"4","author":"Jeremiah ZA","year":"2012","journal-title":"Int J Womens Health"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.01007.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.08.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-10-0704"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.05.022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.044883"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(95)00073-Z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.940891"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.046"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.10.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.08.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2017.60.6.542"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2012.09.019"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmw001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2018.1529734"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.13163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:59:41Z","timestamp":1693893581000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,21]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/ijgo.13163"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13163","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,21]]},"assertion":[{"value":"2019-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}