{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:09:22Z","timestamp":1785420562791,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the chance of live birth after several oocyte retrieval cycles in patients with diminished ovarian reserve (<jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content>) and identify the possible predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 931 patients with <jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content> who underwent in vitro fertilization at a university hospital in China between January 2012 and December 2014. All data for fresh and the associated frozen\u2010thawed embryo transfer attempts were analyzed. Conditional and cumulative live birth rates (<jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content>s) were calculated. Mediation and logistic regression analyses were performed to determine the predictors of live birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conditional <jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content>s remained around 10.0% in the first five cycles. Conservative cumulative <jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">CLBR<\/jats:styled-content>s) reached 22.0% after three cycles and increased to 24.8% after six cycles; optimal <jats:styled-content style=\"fixed-case\">CLBR<\/jats:styled-content>s increased from 12.9% to nearly 50.0% after six cycles. Patient age and the number of good\u2010quality embryos were two key predictors in determining the conditional and conservative <jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For patients with <jats:styled-content style=\"fixed-case\">DOR<\/jats:styled-content>, conditional <jats:styled-content style=\"fixed-case\">LBR<\/jats:styled-content> remained constant in the first five cycles, and patients should be encouraged to continue to three or five completed cycles to maximize their chance of live birth. Patient age and the number of good\u2010quality embryos were two key factors to predict live birth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13174","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T18:34:45Z","timestamp":1587321285000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of live birth rate in women with diminished ovarian reserve"],"prefix":"10.1002","volume":"150","author":[{"given":"Rui","family":"Huang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning\u2010Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Sixth Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92439-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.02.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2017.60.1.46"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0595-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1102879"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12710"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00461"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092"},{"key":"e_1_2_8_12_1","unstructured":"R Core Team.R: A language and environment for statistical computing. 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