{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:54:24Z","timestamp":1784735664248,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether neutrophil\u2010to\u2010lymphocyte ratio (NLR), a well\u2010established inflammatory marker, can be used as an early predictor for small\u2010for\u2010gestational\u2010age (SGA) neonates and other adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study compared first\u2010trimester hematological biomarkers in pregnancies of patients with and without SGA (n=149, n=151, respectively). Demographic, clinical, and obstetrical characteristics and first\u2010trimester complete blood count were retrieved. Woman with singleton pregnancies who delivered at Soroka University Medical Center between January 2015 and December 2016 were included. Patients with known maternal infections, relevant medications, hematological conditions, and chronic diseases that may alter the blood count, those with multiple pregnancies, and those with congenital or chromosomal abnormalities were excluded. After univariate analysis, a linear regression model was constructed to assess the association between hematological indices and SGA. Receiver operating curves were constructed to evaluate the sensitivity and specificity of NLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First\u2010trimester NLR values of the SGA group were significantly higher compared to controls (3.03\u00a0\u00b1\u00a01.68 vs 2.63\u00a0\u00b1\u00a01.2, <jats:italic>P<\/jats:italic>=0.016). Significantly higher levels of NLR were noted among the severely (&lt;3%) SGA neonates (3.12\u00a0\u00b1\u00a01.62 vs 2.62\u00a0\u00b1\u00a01.2; <jats:italic>P<\/jats:italic>=0.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NLR may be an early, clinically useful marker in the prediction of SGA. As blood samples are routinely collected, correct implication of this result may serve as a valuable non\u2010invasive, low\u2010cost, readily available predicting tool.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13230","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:16:20Z","timestamp":1590005780000},"page":"340-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early predictors of small\u2010for\u2010gestational\u2010age neonates using non\u2010invasive, low\u2010cost, and readily available hematological markers"],"prefix":"10.1002","volume":"150","author":[{"given":"Ofir","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Gynecology A Ward Soroka University Medical Center Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gali","family":"Pariente","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gynecology A Ward Soroka University Medical Center Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reut","family":"Rotem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shaare Zedek Medical Center affiliated with the Hebrew University Medical School of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yohai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gynecology A Ward Soroka University Medical Center Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi Y.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gynecology A Ward Soroka University Medical Center Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.08.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3677"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"S5","article-title":"Levels and patterns of intrauterine growth retardation in developing countries","volume":"52","author":"Onis M","year":"1998","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007113.pub2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2009.0178"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(03)00060-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1606171"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612459675"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.11.012"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.905910"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.07.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3533-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2016.12.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-007-0071-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0681-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"BersaniI PiaM DirkDC ToniF DianaE SaraR et al.Interleukin\u201022: Biomarker of maternal and fetal inflammation?2014.","DOI":"10.1007\/s12026-014-8568-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2603-0"},{"key":"e_1_2_7_19_1","first-page":"311","article-title":"Birth weight standards in the live\u2010born population in Israel","volume":"7","author":"Dollberg S","year":"2001","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1237497"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.10.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.09.007"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.12.2702"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.07.017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.05.039"}],"container-title":["International Journal of Gynecology &amp; 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