{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:27:34Z","timestamp":1770769654380,"version":"3.50.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of folate receptor\u2010mediated tumor detection (FRD) for identifying high\u2010grade intraepithelial squamous lesions (HSIL) in the triage of women who are positive for human papillomavirus (HPV), and those with cytology findings of atypical squamous cells of undetermined significance (ASCUS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A secondary analysis of prospectively collected data from 1504 women who had abnormal results during primary cervical cancer screening at 13 hospitals in Beijing, China, between November 2014 and August 2015. The detection accuracy of FRD was evaluated among HPV\u2010positive women and women with ASCUS referred for colposcopy examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1338 women with HPV, the percentage coincidence with pathology findings was higher for FRD (66.7%) than for cytology of ASCUS or higher (51.5%). The rate of colposcopy referral for cytology and FRD as a triage tool was 969 (72.4%) and 736 (55.0%), respectively. Thus, 233 (17.4%) fewer women would be referred for colposcopy by FRD. Among 476 women with cytology of ASCUS, the percentage coincidence with pathology findings was higher for FRD (63.4%) than for HPV (35.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FRD was found to be a promising triage tool for women who are HPV\u2010positive and those with cytology findings of ASCUS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13245","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T23:10:53Z","timestamp":1590793853000},"page":"379-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of folate receptor\u2010mediated tumor detection as a triage tool in cervical cancer screening"],"prefix":"10.1002","volume":"150","author":[{"given":"Yun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People\u2019s Hospital Beijing 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