{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:58:56Z","timestamp":1774558736896,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether primary conization might overcome the risk of local dissemination in patients undergoing laparoscopic radical hysterectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive data of 262 patients with early stage cervical cancer were retrieved: 88 women had conization followed by radical hysterectomy. A propensity\u2010matched comparison (1:1) was carried out in order to compare laparoscopy and open surgery. Accumulating data highlighted that minimally invasive surgery has been associated with higher recurrence rates and worse overall survival than open surgery in women with early stage cervical cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data of 35 paired patients (total 70 patients) were analyzed. No between\u2010group differences in baseline, disease, and pathological variables were observed. Patients undergoing laparoscopy correlated with lower blood loss (50 [range 30\u2013100] vs 150 [range 50\u2013500] mL; <jats:italic>P<\/jats:italic>&lt;0.001) and shorter length of stay (3\u00a0\u00b1\u00a00.8 vs 5.4\u00a0\u00b1\u00a01.4\u00a0days; <jats:italic>P<\/jats:italic>&lt;0.001) compared to open surgery. One local recurrence was observed per group (<jats:italic>P<\/jats:italic>=1.00). Type of surgical approach did not influence site of recurrence (<jats:italic>P<\/jats:italic>=1.00) or survival outcomes, in terms of 10\u2010year disease\u2010free (<jats:italic>P<\/jats:italic>=0.549, log\u2010rank test) and overall survivals (<jats:italic>P<\/jats:italic>=0.615, log\u2010rank test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data show that primary conization might overcome the risk of local recurrence after laparoscopic radical hysterectomy in early stage cervical cancer. Further prospective evidence is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13260","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T18:55:21Z","timestamp":1591642521000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Primary conization overcomes the risk of developing local recurrence following laparoscopic radical hysterectomy in early stage cervical cancer"],"prefix":"10.1002","volume":"151","author":[{"given":"Giorgio","family":"Bogani","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Ditto","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Chiappa","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Pinelli","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Sonetto","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"issue":"10","key":"e_1_2_7_2_1","first-page":"CD006655","article-title":"Laparoscopy versus laparotomy for the management of early stage endometrial cancer","author":"Galaal K","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.07.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001381"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.01.092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.12.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806395"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804923"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2018.120"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.10.026"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-85014-1_2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350612472986"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6031-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e27"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2017.28.e82"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2014.03.018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.08.233"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12702"}],"container-title":["International Journal of Gynecology &amp; 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