{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:14:52Z","timestamp":1777558492394,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether addition of letrozole to a misoprostol\u2010based abortion regimen can increase the rate of complete abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The randomized, placebo\u2010controlled, double\u2010blind trial enrolled women with missed abortion in the first trimester of pregnancy attending Sadooghi Hospital, Isfahan, Iran, from 2016 to 2018. The women were randomly assigned to the study group, which received 10\u00a0mg of letrozole daily for 3\u00a0days, followed by two doses of 800\u00a0\u03bcg of vaginal misoprostol at a 4\u2010hour interval, or the control group, which received a placebo, followed by the same dose of misoprostol. Sonography was performed to check the abortion status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 120 women completed the study: 60 in the misoprostol plus letrozole group, and 60 in the misoprostol only group. Complete abortion was documented for 93 (77.5%) women: 48 (80.0%) in the misoprostol plus letrozole group and 45 (75.0%) in the misoprostol only group (<jats:italic>P<\/jats:italic>=0.80). The mean duration of induction in the misoprostol plus letrozole and misoprostol only groups was 7.35\u00a0\u00b1\u00a03.54\u00a0hours and 8.2\u00a0\u00b1\u00a03.8 4hours, respectively (<jats:italic>P<\/jats:italic>=0.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of misoprostol alone was found to be as effective as the administration of misoprostol plus letrozole for first\u2010trimester missed abortion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13326","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:35:30Z","timestamp":1595464530000},"page":"214-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of misoprostol with and without letrozole on the induction of abortion for women with first\u2010trimester missed abortion"],"prefix":"10.1002","volume":"151","author":[{"given":"Zahra","family":"Allameh","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Goharian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Eslamian","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009388"},{"issue":"1","key":"e_1_2_8_3_1","first-page":"CD007223","article-title":"Medical treatments for incomplete miscarriage","author":"Kim C","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044064"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01892-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.811111.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00998.x"},{"issue":"11","key":"e_1_2_8_8_1","first-page":"CD002855","article-title":"Medical methods for first trimester abortion","author":"Kulier R","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","first-page":"427","article-title":"Comparison of vaginal misoprostol, combined letrozole and misoprostol and combined laminaria and misoprostol in the preparation of second\u2010trimester cervical abortion","volume":"17","author":"Kahnamooi F","year":"2018","journal-title":"J Ardabil Univ Med Sci"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200204000-00009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70235-3"},{"key":"e_1_2_8_12_1","first-page":"700","article-title":"Letrozole and misoprostol versus misoprostol alone for termination of pregnancy: A randomized clinical trial","volume":"71","author":"Rezai Z","year":"2014","journal-title":"Tehran Univ Med J"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.165964"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.03.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-4-26"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.296.3361"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0374-9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.3.709"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-1949-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-122499"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.30699\/jogcr.3.2.49","article-title":"Comparison of using misoprostol with or without letrozole in abortion induction. 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