{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:37:40Z","timestamp":1770359860792,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the safety of the levonorgestrel 52\u2010mg intrauterine system (LNG\u2010IUS) in women with a history of thrombosis or coagulopathy and to evaluate bleeding patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted of 117 women attending a clinic between 2007 and 2019. Their sociodemographic characteristics, hematologic status, reasons for using LNG\u2010IUS, duration of use, use of oral anticoagulants, complications, and bleeding patterns were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010nine women had a history of thrombosis (71.7% in use of oral anticoagulants) and 18 had coagulopathies. No bleeding or any other complications occurred during placement of the LNG\u2010IUS. Around two\u2010thirds of the women reported amenorrhea or oligomenorrhea at 12, 24, and 54\u00a0months of follow\u2010up, with no difference between the groups using the IUS for contraception or to treat heavy menstrual bleeding (HMB) (<jats:italic>P<\/jats:italic>=0.07), those with a history of thrombosis or coagulopathy (<jats:italic>P<\/jats:italic>=0.53), and users or non\u2010users of oral anticoagulants (<jats:italic>P<\/jats:italic>=0.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The LNG\u2010IUS is safe for women with hematologic disorders. It was associated with amenorrhea or oligomenorrhea in a large proportion of users up to 54\u00a0months of follow\u2010up regardless of use of oral anticoagulants, reason for use of LNG\u2010IUS (contraception or HMB), or history of coagulopathy or thrombosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13378","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T20:05:46Z","timestamp":1600891546000},"page":"355-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety and bleeding patterns of the levonorgestrel 52\u2010mg intrauterine system among women with thrombosis or coagulopathy"],"prefix":"10.1002","volume":"151","author":[{"given":"Eliza P.","family":"Brull","sequence":"first","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology University of Campinas Medical School Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlete","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology University of Campinas Medical School Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilza","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology University of Campinas Medical School Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Bahamondes","sequence":"additional","affiliation":[{"name":"Family Planning Clinic Department of Obstetrics and Gynecology University of Campinas Medical School Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia R. 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