{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:52:47Z","timestamp":1770900767021,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin\u2010releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) can improve the number of retrieved oocytes and clinical pregnancy rate in poor responders undergoing in vitro fertilization\/intracytoplasmic sperm injection (IVF\u2010ICSI) cycles using a GnRH\u2010antagonist protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH\u2010antagonist protocol. They were divided equally into two groups: group I received 10\u00a0000 units of hCG plus 0.2\u00a0mg of triptorelin while group II received 10\u00a0000 units of hCG only for triggering of ovulation. The primary outcome parameter was the number of oocytes retrieved. Secondary outcomes included metaphase II oocytes number, cancellation rate, number of obtained embryos, chemical and clinical pregnancy rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty women were included in the study, with 80 women in each treatment group. Dual triggering was associated with higher number of retrieved oocytes (5.3\u00a0\u00b1\u00a01.9 vs 4.5\u00a0\u00b1\u00a02.4, <jats:italic>P<\/jats:italic>=0.014), metaphase II oocytes (3.8\u00a0\u00b1\u00a01.4 vs 3.1\u00a0\u00b1\u00a01.7, <jats:italic>P<\/jats:italic>=0.004), total and grade 1 embryos (2.7\u00a0\u00b1\u00a01.1 and 2.3\u00a0\u00b1\u00a01.0 vs 1.9\u00a0\u00b1\u00a01.2 and 1.1\u00a0\u00b1\u00a00.2, <jats:italic>P<\/jats:italic>=0.001 and 0.021 respectively), and transferred embryos (2.2\u00a0\u00b1\u00a00.9 vs 1.6\u00a0\u00b1\u00a00.9, <jats:italic>P<\/jats:italic>=0.043, and lower cancellation rate (7.5% vs 20%, <jats:italic>P<\/jats:italic>=0.037) compared with single triggering. There were significantly higher chemical (25% vs 11.3%, <jats:italic>P<\/jats:italic>=0.039) and clinical (22.5% vs 8.8%, <jats:italic>P<\/jats:italic>=0.028) pregnancy rates in women with dual triggering compared with those with single triggering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dual triggering is associated with better IVF outcome in poor responders compared with single trigger.<\/jats:p><jats:p>\n<jats:bold>Clinical trial registration NCT04008966.<\/jats:bold>\n<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13405","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T11:35:05Z","timestamp":1601811305000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparative study between single versus dual trigger for poor responders in GnRH\u2010antagonist ICSI cycles: A randomized controlled study"],"prefix":"10.1002","volume":"152","author":[{"given":"Ahmed M.","family":"Maged","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Ragab","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Shohayeb","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Saber","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Ekladious","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman A.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akmal","family":"El\u2010Mazny","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Hany","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Kasr Alainy Hospital Cairo University Cairo 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hormone agonist versus HCG for oocyte triggering in antagonist assisted reproductive technology cycles","volume":"1","author":"Youssef MA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.015"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1316"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2016.1193141"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13021"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090359"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1976"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.978850"},{"key":"e_1_2_8_26_1","unstructured":"ErdemA MutluMF ErdemM MutluI;Department of Obstetrics & Gynecology Gazi University Faculty of Medicine Ankara Turkey 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