{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:47:06Z","timestamp":1789426026580,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate whether the estradiol\/oocyte ratio (E\n                      <jats:sub>2<\/jats:sub>\n                      \/O) can predict ovarian response and pregnancy outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective cohort study on 1838 individuals undergoing in vitro fertilization with a depot gonadotropin\u2010releasing hormone agonist (GnRH\u2010a) long protocol. The patients were grouped by the quartiles of E\n                      <jats:sub>2<\/jats:sub>\n                      \/O: &lt;131.2, 131.2\u2013178.0, 178.0\u2013242.9, and &gt;242.9\u00a0pg\/mL. ANOVA and \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test with the Bonferroni adjustment were used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With the rise of E\n                      <jats:sub>2<\/jats:sub>\n                      \/O, the MII oocyte rate increased, whereas the number of oocytes retrieved decreased. The number of MII oocytes, fertilization rate, and the number of high\u2010grade embryos were similar among the four groups. There were no differences in live\u2010birth rate, clinical pregnancy rate, ectopic pregnancy rate, and miscarriage rate, but there was a trend towards a higher miscarriage rate in the patients with E\n                      <jats:sub>2<\/jats:sub>\n                      \/O between 131.2 and 242.9\u00a0pg\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      E\n                      <jats:sub>2<\/jats:sub>\n                      \/O indicates the percentage of MII oocytes, but not the quality of an individual follicle. E\n                      <jats:sub>2<\/jats:sub>\n                      \/O does not predict live birth in a depot GnRH\u2010a long protocol; however, there is a trend towards a higher risk for miscarriage in the patients with E\n                      <jats:sub>2<\/jats:sub>\n                      \/O between 131.2 and 242.9\u00a0pg\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13417","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T04:02:24Z","timestamp":1602388944000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The estradiol\/oocyte ratio predicts the MII oocyte rate, but not live\u2010birth rate in a depot gonadotropin\u2010releasing hormone agonist long protocol"],"prefix":"10.1002","volume":"153","author":[{"given":"Jihui","family":"Ai","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingji","family":"Gong","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Chen","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.08.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1101437"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-005-1494-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-019-2056-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw027"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.4.1438"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(99)00038-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.491168"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.036"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00569-0"},{"key":"e_1_2_8_14_1","first-page":"11","article-title":"High peak estradiol\/mature oocyte ratio predicts lower clinical pregnancy, ongoing pregnancy, and live birth rates in GnRH antagonist intracytoplasmic sperm injection cycles","volume":"61","author":"Sandoval JS","year":"2016","journal-title":"J Reprod Med"},{"key":"e_1_2_8_15_1","first-page":"434","article-title":"Elevated E2: oocyte ratio in women undergoing IVF and tubal ET. 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