{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:21:16Z","timestamp":1791656476034,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the efficacy and safety of intra\u2010cardiac lidocaine administration to induce fetal demise before second\u2010trimester medication abortion in a teaching hospital in Addis Ababa, Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective chart review to collect selected sociodemographic and clinical information. All patients who received fetal intra\u2010cardiac lidocaine between January 1, 2019 and April 30, 2019 were included in the study. Fetal demise was considered successful if achieved within 24\u00a0hours after fetal intra\u2010cardiac lidocaine administration. We analyzed the data using SPSS version 20. We used frequency tables to describe the data and performed a multivariable analysis to determine associations between variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 80 fetuses were given intra\u2010cardiac lidocaine.The mean gestational age was 23\n                      <jats:sup>+1<\/jats:sup>\n                      \u00a0weeks (range 21\n                      <jats:sup>+0<\/jats:sup>\n                      \u201327\n                      <jats:sup>+5<\/jats:sup>\n                      \u00a0weeks). Twenty\u2010four hours after lidocaine administration 76 (95%) pregnancies showed negative fetal cardiac activity. Fetuses at gestational ages of 21\u201323\n                      <jats:sup>+6<\/jats:sup>\n                      \u00a0weeks were five times more likely to have negative cardiac activity compared with those with gestational ages between 24 and 28\u00a0weeks (\n                      <jats:italic>P<\/jats:italic>\n                      =0.001). Two women developed nausea, vomiting, and a metallic taste, but no serious adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intra\u2010cardiac lidocaine is effective at inducing fetal demise before late second\u2010trimester medication abortion with no associated serious adverse events or complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13419","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T04:47:16Z","timestamp":1602478036000},"page":"125-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intra\u2010cardiac lidocaine administration to induce fetal demise before late second\u2010trimester abortion: Retrospective review"],"prefix":"10.1002","volume":"153","author":[{"given":"Lemi Belay","family":"Tolu","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Saint Paul's Hospital Millennium Medical College Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfaye H.","family":"Tufa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Saint Paul's Hospital Millennium Medical College Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferid","family":"Abas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Saint Paul's Hospital Millennium Medical College Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavi","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"MacAfee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science University of Vermont Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Prager","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Saint Paul's Hospital Millennium Medical College Addis Ababa Ethiopia"},{"name":"Department of Obstetrics &amp; Gynecology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.05.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000263948"},{"key":"e_1_2_10_4_1","first-page":"471","article-title":"Digoxin to facilitate late second\u2010trimester abortion: A randomized, masked, placebo\u2010controlled trial","volume":"97","author":"Jackson RA","year":"2001","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.08.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.01.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00797.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.10.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116740"},{"key":"e_1_2_10_10_1","first-page":"310","article-title":"Fetal intracardiac potassium chloride injection to avoid the hopeless resuscitation of an abnormal abortus: II. 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