{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:12:41Z","timestamp":1753884761786},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between estradiol (E<jats:sub>2<\/jats:sub>) levels on the day of human chorionic gonadotropin (hCG) administration and embryo quality during in vitro fertilization (IVF) cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of 6676 IVF cycles among women treated at the Reproductive Center of The First Affiliated Hospital of USTC, Hefei, China, from June 2014 to May 2017. E<jats:sub>2<\/jats:sub> levels on hCG day were divided into four groups by 25th percentile: 0\u20131763\u00a0pg\/mL (group I), 1763\u20133692\u00a0pg\/mL (group II), 3692\u20134800\u00a0pg\/mL (group III), and higher than 4800\u00a0pg\/mL (group IV). Analysis of variance and multiple linear regression were used to test associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in the frequency of high\u2010quality embryos between group I (51.6\u00a0\u00b1\u00a01.1%) and groups II (65.6\u00a0\u00b1\u00a00.8%), III (62.1\u00a0\u00b1\u00a00.7%), and IV (62.3\u00a0\u00b1\u00a00.7%). Using E<jats:sub>2<\/jats:sub> as a dummy variable and group II as a control, multiple linear regression showed that E<jats:sub>2<\/jats:sub> levels were associated with the frequency of high\u2010quality embryos obtained (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum E<jats:sub>2<\/jats:sub> on hCG day had an impact on embryo quality. Higher E<jats:sub>2<\/jats:sub> levels did not produce the most high\u2010quality embryos; the highest frequencies were achieved for E<jats:sub>2<\/jats:sub> levels within 1763\u20133692\u00a0pg\/mL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13443","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T01:01:26Z","timestamp":1603933286000},"page":"358-364","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does the elevated estradiol level on the day of human chorionic gonadotropin administration affect embryo quality among women undergoing in vitro fertilization?"],"prefix":"10.1002","volume":"152","author":[{"given":"Ye","family":"Meng","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian\u2010Hong","family":"Tong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu223"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199415000325"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3362"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10086"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0240-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02018-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-119"},{"issue":"10","key":"e_1_2_8_9_1","first-page":"137","article-title":"Comparison of different stimulation protocols used in in vitro fertilization: a review","volume":"3","author":"Shrestha D","year":"2015","journal-title":"Ann Transl Med"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000177"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.01.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01133388"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep290"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.83"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4242-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.178631"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0434-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.066"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-015-0687-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.03.028"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2349"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep273"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(85)90057-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493779"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-7-116"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22951"}],"container-title":["International Journal of Gynecology &amp; 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