{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T14:32:29Z","timestamp":1745850749042},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butylbromide on the duration of the first stage of labor among nulliparous women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized double\u2010blind placebo\u2010controlled study among 126 nulliparous women admitted in the active phase of labor to a teaching hospital in Sagamu, Nigeria, from January to August 2018. Based on the inclusion criteria, women were recruited and randomized to the study or control group, and given intravenous hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butylbromide 20\u00a0mg (1\u00a0mL) or sterile water (1\u00a0mL), respectively, during the active phase. Labor progress and outcomes were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean\u00a0\u00b1\u00a0SD duration of active phase of first stage of labor was significantly shorter in the hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butylbromide group (324.9\u00a0\u00b1\u00a0134.6\u00a0min) than in the control group (392.7\u00a0\u00b1\u00a0119.6\u00a0min) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). The rate of cervical dilatation was 1.4\u00a0\u00b1\u00a00.8\u00a0cm\/h in the hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butylbromide group and 1.0\u00a0\u00b1\u00a00.5\u00a0cm\/h in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). There were no significant differences in fetal heart rate, maternal vital signs, or Apgar scores between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hyoscine\u2010<jats:italic>N<\/jats:italic>\u2010butylbromide was found to be effective in shortening the duration of the first stage of labor without adverse outcomes for mother or neonate.<\/jats:p><jats:p>The trial was registered with the Pan African Clinical trials Registry (PACTR), protocol number: PACTR201808146688942 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=3532\">https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=3532<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13444","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:06:13Z","timestamp":1603919173000},"page":"254-259","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of hyoscine\u2010<i>N<\/i>\u2010butylbromide on labor duration among nullipara in a southwestern Nigerian teaching hospital: A randomized controlled trial"],"prefix":"10.1002","volume":"153","author":[{"given":"Adeniyi K.","family":"Akiseku","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Olabisi Onabanjo University Ago Iwoye Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olusoji E.","family":"Jagun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adebayo A.","family":"Akadri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Babcock University Teaching Hospital Ilishan\u2010Remo Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John O.","family":"Imaralu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Babcock University Teaching Hospital Ilishan\u2010Remo Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adetola O.","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewale O.","family":"Sule\u2010Odu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmu.2015.01.001"},{"key":"e_1_2_8_3_1","first-page":"408","volume-title":"Williams Obstetrics","author":"Cunnigham GF","year":"2014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S16415"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"408","article-title":"Effect of hyoscine butylbromide first stage of labor in multiparous","volume":"12","author":"Sekhavat L","year":"2012","journal-title":"Afr Health Sci"},{"issue":"1","key":"e_1_2_8_6_1","first-page":"1","article-title":"A randomised controlled study of intramuscular camylofin dihydrochloride vs intravenous hyoscine butylbromide in 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