{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:07:25Z","timestamp":1789578445792,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to identify predictors of cervical stromal involvement in women with endometrioid\u2010type endometrial cancer (EEC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 795 patients with EEC who underwent comprehensive surgical staging including pelvic and para\u2010aortic lymph node dissection between January 2007 and December 2018 were retrospectively analyzed. Data including age, menopausal status, serum CA\u2010125 levels, tumor size, lymphovascular space invasion (LVSI), depth of myometrial invasion, positive peritoneal cytology, cervical stromal involvement, histologic grade, recurrence, and follow\u2010up duration were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow up was 49\u00a0months. Cervical stromal invasion was found in 88 patients. Multivariate analysis revealed that presence of LVSI (hazard ratio [HR] 2, 95% confidence interval [CI] 1.02\u20134.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.045), a primary tumor diameter of at least 3\u00a0cm (HR 3, 95% CI 1.31\u20137.25,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.010), and at least 50% deep myometrial invasion (HR 2.7, 95% CI 1.37\u20135.41,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004) were independent risk factors for cervical stromal involvement in patients with EEC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study results suggest that presence of LVSI, a primary tumor diameter of at least 3\u00a0cm, and LVSI of at least 50% seem to be independent predictors of cervical involvement in women with EEC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13449","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T03:16:05Z","timestamp":1603941365000},"page":"51-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk factors for cervical stromal involvement in endometrioid\u2010type endometrial cancer"],"prefix":"10.1002","volume":"153","author":[{"given":"Serhat","family":"Toprak","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda Adeviye","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Malatya Education and Research Hospital Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanifi","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Malatya Education and Research Hospital Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Aytac","family":"Tohma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Baskent University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ercan","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mutlu","family":"Meydanli","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Ankara City Hospital Faculty of Medicine University of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2014.25.2.105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016924109171580"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1963.tb00327.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03341.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6346"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12321"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182073ac0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.12.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.v18.i1-2.40"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.03.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-011-0351-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f73fc2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5501"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.018"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000260871.87607.25"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.08.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.11.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv484"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05276-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.11.016"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001229"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.11.033"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12089"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3609-6"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:53:21Z","timestamp":1773003201000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/ijgo.13449"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13449","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"2020-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}