{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:39:34Z","timestamp":1773009574525,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the predictive value of serum human epididymis protein 4 (HE4) marker in the preoperative prediction of the risk of advanced disease in the endometrioid subtype of endometrial cancer, and its association with poor prognostic factors. In addition, a cut\u2010off value of HE4 was defined to classify patients according to these results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective and multicenter cohort analytical pilot study of patients operated for endometrial cancer at the Miguel Servet University Hospital of Zaragoza (Spain) and the Complejo Universitario of Le\u00f3n (Spain) from January 2017 to May 2019. Preoperative serum levels of HE4 were analyzed by clinical and pathologic characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all, 126 patients were included. A statistically significant association was found between the preoperative HE4 value and node involvement (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008), late\u2010stage disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003), high histologic grade (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007), deep myometrial invasion (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001), lymphovascular space invasion (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001), and other pathologic factors. In addition, an HE4 cut\u2010off value (156.4\u00a0pmol\/L) has been determined to predict, preoperatively, which patients will present with early stage disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The preoperative marker HE4 is a useful tool in the preoperative study of patients with endometrial cancer as it relates to late\u2010stage disease as well as other prognostic factors in the endometrioid subtype of endometrial cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13473","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T10:46:56Z","timestamp":1604659616000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Value of preoperative HE4 as predictor of advanced disease in endometrioid endometrial cancer"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1742-5617","authenticated-orcid":false,"given":"Andrea","family":"Espiau Romera","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-2015","authenticated-orcid":false,"given":"Pluvio Jes\u00fas","family":"Coronado Mart\u00edn","sequence":"additional","affiliation":[{"name":"Women\u2019s Health Institute Hospital Clinico San Carlos IdISSC. Complutense University of Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-0682","authenticated-orcid":false,"given":"Marta","family":"Ch\u00f3liz Ezquerro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-9050","authenticated-orcid":false,"given":"Tatiana","family":"Cuesta Guardiola","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Complejo Universitario of Le\u00f3n Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7184-2529","authenticated-orcid":false,"given":"Ignacio","family":"Adiego Calvo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-8995","authenticated-orcid":false,"given":"Laura","family":"Baquedano Mainar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Miguel Servet University Hospital Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000609"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod45.2.350"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606092"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000120"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61766-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_130_18"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13140"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428318757103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0583-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3049-3"},{"issue":"7","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/IGC.0b013e3182229ad8","article-title":"Utility of tumor marker HE4 to predict depth of myometrial invasion in endometrioid adenocarcinoma of the uterus","volume":"21","author":"Moore RG","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2015.07.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.109"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.04.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22223"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2115-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0757"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05276-9"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1190-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.05.015"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.3.1489"}],"container-title":["International Journal of Gynecology &amp; 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