{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:05:18Z","timestamp":1761491118352},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of gonadotropin\u2010stimulated and human chorionic gonadotropin (hCG) \u2010primed in vitro oocyte maturation (IVM) in cases of repeated in vitro fertilization (IVF) failure due to various forms of oocyte maturation arrest (OMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz &amp; Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved in the IVM than in the IVF cycles. No embryos were produced from oocytes collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 embryos and 6 (31.6%) day 3 embryos were obtained. The difference between the groups was statistically significant (<jats:italic>P\u00a0= 0.001, P\u00a0= 0.002, respectively<\/jats:italic>). Single day 3 embryo transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follicle\u2010stimulating hormone\u2010stimulated and hCG\u2010primed IVM does not improve oocyte maturation, developmental potential, or pregnancy rates of women with OMA. Future studies directed to re\u2010establishing normal cytoskeletal architecture and machinery, and resumption of meiosis may be beneficial for obtaining mature oocytes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13490","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T06:49:25Z","timestamp":1605941365000},"page":"496-502","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Can in vitro maturation overcome cycles with repeated oocyte maturation arrest? A classification system for maturation arrest and a cohort study"],"prefix":"10.1002","volume":"153","author":[{"given":"Safak","family":"Hatirnaz","sequence":"first","affiliation":[{"name":"IVF\u2010IVM Center Medicana International Hospital Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"Ba\u015fbu\u011f","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology School of Medicine D\u00fczce University D\u00fczce Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Hatirnaz","sequence":"additional","affiliation":[{"name":"IVF\u2010IVM Center Medicana International Hospital Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Tannus","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Galilee Medical Center affiliated to Bar\u2010Ilan University Naharia Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaan","family":"Hatirnaz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Faculty of Science Ondokuzmay\u0131s University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Bakay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology School of Medicine Ondokuzmay\u0131s University Samsun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of obstetrics gynecology McGill University Montreal Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.02.037"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.03.040"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1317-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JARG.0000013651.37866.0c"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjod.22804"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2006-0408"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200604140"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng931"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.05.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518778638"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2556"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0050"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:50:27Z","timestamp":1693554627000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ijgo.13490"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13490","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,21]]},"assertion":[{"value":"2020-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}