{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:21:19Z","timestamp":1694596879339},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate trappin\u20102 levels in cervicovaginal secretions for prediction of spontaneous preterm birth (sPTB) and compare it with transvaginal sonography (TVS) cervical length in asymptomatic women at risk of PTB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Trappin\u20102 levels assessed in cervicovaginal secretions collected from 80 asymptomatic pregnant women at high risk for preterm delivery and cervical length measured by TVS, first at 14\u201320\u00a0weeks of pregnancy and repeated 8\u00a0weeks later. On the basis of delivery outcomes, participants were divided into cases (delivery &lt;37\u00a0weeks) and controls (delivery at 37\u201341\u00a0weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean value of cervicovaginal trappin\u20102 was significantly higher in women who delivered preterm (n\u00a0=\u00a040), compared with the term group (n\u00a0=\u00a040: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) both at 14\u201320\u00a0weeks and at 22\u201328\u00a0weeks. The critical cut\u2010off value for cervicovaginal trappin\u20102 at 14\u201320\u00a0weeks was 4620\u00a0pg\/mL, above which participants delivered prematurely with sensitivity, specificity, and positive and negative predictive values of 82.5%, 71.0%, 78.5%, and 81.5% respectively, whereas TVS cervical length in this window period was not significantly associated with preterm birth. At 22\u201328\u00a0weeks a trappin\u20102 value of 6900\u00a0pg\/mL had similar predictive accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Raised cervicovaginal trappin\u20102 levels can be used as an early tool for prediction of PTB as early as 14\u201320\u00a0weeks (earlier than TVS) in asymptomatic high\u2010risk women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13512","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T20:02:16Z","timestamp":1607112136000},"page":"56-61","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of trappin\u20102 in cervicovaginal secretions as predictor of spontaneous preterm birth in asymptomatic high\u2010risk women: Nested case\u2010control study"],"prefix":"10.1002","volume":"154","author":[{"given":"Deepika","family":"Negi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology UCMS and GTB Hospital Dilshad Garden Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Guleria","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UCMS and GTB Hospital Dilshad Garden Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipin","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry UCMS and GTB Hospital Dilshad Garden Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basu","family":"Dev Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry UCMS and GTB Hospital Dilshad Garden Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Suneja","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology UCMS and GTB Hospital Dilshad Garden Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_8_3_1","volume-title":"March of Dimes, PMNCH, save the children, WHO. 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