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Genetic polymorphisms associated with individual differences and variations might be related to complex disorders with unknown causes, including PCOS. Several leading genetic markers with known cellular functions have been identified among Iranian women presenting with PCOS. In particular, the existing evidence shows a significant relationship between PCOS and the following genetic polymorphisms: rs2275913 (interleukin\u201017A), rs9927163 (interleukin\u201032), Pro12Ala (peroxisome proliferator\u2010activated receptor\u2010\u03b3), rs17173608 (chemerin), rs2236242 (vaspin), ApaI (vitamin D receptor), and rs7895833 (sirtuin 1). In addition, a higher risk of PCOS is associated with the rs2910164 (microRNA 146a), rs2241766 (adiponectin), \u201334\u00a0T\/C (cytochrome 17), and rs1800682 (Fas) polymorphisms. Furthermore, protective effects against PCOS have been reported for the A4223C polymorphism of adenosine deaminase 1. Overall, the available data indicate that Iranian women with PCOS have a higher prevalence of polymorphisms in inflammation\u2010 and metabolism\u2010related genes, but not in insulin\u2010related genes. More extensive studies are needed to identify the ethnicity\u2010related genetic associations in PCOS.<\/jats:p>","DOI":"10.1002\/ijgo.13534","type":"journal-article","created":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T05:51:14Z","timestamp":1607752274000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic polymorphisms associated with polycystic ovary syndrome among Iranian women"],"prefix":"10.1002","volume":"153","author":[{"given":"Mohammad","family":"Jamshidi","sequence":"first","affiliation":[{"name":"Department of Laboratory Sciences School of Allied Medicine Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Mohammadi Pour","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Bahadoram","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-5661","authenticated-orcid":false,"given":"Mohammad\u2010Reza","family":"Mahmoudian\u2010Sani","sequence":"additional","affiliation":[{"name":"Thalassemia and Hemoglobinopathy Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Saeedi Boroujeni","sequence":"additional","affiliation":[{"name":"Department of Immunology Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"ImmunologyToday Universal Scientific Education and Research Network Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03275-2"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064801"},{"issue":"7","key":"e_1_2_13_4_1","first-page":"907","article-title":"Epigenetics of polycystic ovary syndrome","volume":"145","author":"Concha C","year":"2017","journal-title":"Rev Med Chile"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0449"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.11.008"},{"key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-4613-8483-0_4","volume-title":"Polycystic Ovary Syndrome (PCOS): the possible roles of apoptosis in human granulosa cells. 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