{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:18:39Z","timestamp":1770754719459,"version":"3.50.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare 1\u2010 and 2\u2010day drug administration interval between mifepristone and misoprostol for second\u2010trimester pregnancy termination and provide evidence\u2010based recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Search strategy: the search was performed in Pubmed, EMBASE, and Cochrane Library for the relevant published studies from their establishment to March 2020. Selection criteria: randomized controlled trials (RCTs) comparing 1\u2010 and 2\u2010day time interval of mifepristone\u2010misoprostol for termination of pregnancy during second\u2010trimester pregnancy were considered. Data were processed using <jats:sc>Revman<\/jats:sc> 5.3 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Meta\u2010analyses of three RCTs showed no significant difference was reported in the induction\u2010to\u2010abortion time and successful abortion rate between 1\u2010 and 2\u2010day mifepristone and misoprostol intervals. Statistical difference was not identified in the induction\u2010to\u2010abortion time between the two drug administration intervals in nulliparous or parous women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both 1\u2010 and 2\u2010day dosing intervals between mifepristone and misoprostol are suitable for clinical use for second\u2010trimester medical termination of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13541","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T12:01:48Z","timestamp":1608292908000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Different dosing intervals of mifepristone\u2010misoprostol for second\u2010trimester termination of pregnancy: A meta\u2010analysis and systematic review"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-740X","authenticated-orcid":false,"given":"Limei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manman","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gynecology Women and Children's Hospital of Guangdong Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zu","sequence":"additional","affiliation":[{"name":"Department of Neurology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Chengdu Second People\u2019s Hospital Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"CD006714","article-title":"Surgical versus medical methods for second trimester induced abortion","author":"Lohr PA","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","unstructured":"Medical methods for termination of pregnancy. 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