{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:56:35Z","timestamp":1787504195829,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Use of quantitative fetal fibronectin (fFN) testing to predict spontaneous preterm birth (sPTB) is gaining attention owing to its absolute measurement of fFN concentration and increased positive predictive value compared with qualitative testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the predictive values of quantitative fFN for sPTB in different predefined thresholds using systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search strategy<\/jats:title>\n                    <jats:p>Five major databases (PubMed, ScienceDirect, Web of Science, Embase, Cochrane library) were searched for eligible studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection criteria<\/jats:title>\n                    <jats:p>Observational studies of the diagnostic accuracy of different quantitative fFN thresholds on delivery outcomes were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data collection and extraction<\/jats:title>\n                    <jats:p>Articles were reviewed independently by two authors and data were extracted. Sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curves were extracted and calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Fifteen studies were included. To detect sPTB at less than 34\u00a0weeks of gestation, pooled sensitivities for thresholds of 10, 50, 200, and 500\u00a0ng\/ml were 0.78, 0.56, 0.33, and 0.11, respectively. Pooled specificities were 0.63, 0.84, 0.96, and 0.99, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the results of the meta\u2010analysis, the threshold of 10\u00a0ng\/ml fFN may be a new choice for the prediction of sPTB. The improved diagnostic accuracy of quantitative testing over qualitative testing can provide additional discriminatory information for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13550","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T10:35:52Z","timestamp":1608287752000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic accuracy of quantitative fetal fibronectin to predict spontaneous preterm birth: A meta\u2010analysis"],"prefix":"10.1002","volume":"153","author":[{"given":"Jingning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Shantou Jinping Women and Children\u2019s Hospital Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of 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