{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:05Z","timestamp":1790140565565,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#78879"],"award-info":[{"award-number":["#78879"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the associations between risk of pre\u2010eclampsia and pregnancy levels of maternal 25\u2010hydroxyvitamin D (25[OH]D) and oxidative stress biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A nested case\u2013control study (n\u00a0=\u00a099; 34 cases; 65 controls) within a prospective pregnancy cohort. Maternal 25(OH)D and oxidative stress markers (six isomers of F\n                      <jats:sub>2<\/jats:sub>\n                      \u2010isoprostanes; F\n                      <jats:sub>2<\/jats:sub>\n                      \u2010isoPs) were measured in plasma at 12\u201318 and 24\u201326 gestational weeks. Vitamin D deficiency was defined as 25[OH]D less than 50\u00a0nmol\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maternal vitamin D deficiency was associated with increased 8\u2010iso\u2010PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.037), 15(\n                      <jats:italic>R<\/jats:italic>\n                      )\u2010PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004), (\u00b1)5\u2010iPF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      \u2010VI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026) at 12\u201318\u00a0weeks. Vitamin D deficiency was inversely associated with 8\u2010iso\u2010PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.019) and (\u00b1)5\u2010iPF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      \u2010VI isomer (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.010) at 24\u201326\u00a0weeks. Both maternal vitamin D deficiency (adjusted odds ratio [aOR], 4.79; 95% confidence interval [CI], 1.67\u201313.75) and increased (\u00b1)5\u2010iPF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      \u2010VI (aOR, 2.46; 95% CI, 1.16\u20135.22) at 24\u201326\u00a0weeks were associated with risk of pre\u2010eclampsia. However, the interaction test between 25(OH)D and (\u00b1)5\u2010iPF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      \u2010VI was not significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.143).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Plasma 25(OH)D below 50\u00a0nmol\/L was associated with increased oxidative stress levels during pregnancy as measured by two F\n                      <jats:sub>2<\/jats:sub>\n                      \u2010isoP isomers, including the well\u2010studied marker 8\u2010iso\u2010PGF\n                      <jats:sub>2\u03b1<\/jats:sub>\n                      . Whether vitamin D\u2010induced oxidative stress mediates the risk of pre\u2010eclampsia warrants future study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13559","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T16:10:45Z","timestamp":1608653445000},"page":"444-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal vitamin D, oxidative stress, and pre\u2010eclampsia"],"prefix":"10.1002","volume":"154","author":[{"given":"Shu Qin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"},{"name":"Institut National de Sant\u00e9 Publique du Qu\u00e9bec Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Bilodeau","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology and nephrology CHU of Quebec Research Center \u2013 Faculty of Medicine Laval University Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Julien","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology and nephrology CHU of Quebec Research Center \u2013 Faculty of Medicine Laval University Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Cheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Lunenfeld\u2010Tanenbaum Research Institute, Obstetrics and Gynecology Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim A.","family":"Abenhaim","sequence":"additional","affiliation":[{"name":"Jewish General Hospital McGill University Health Centre Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Guang","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Monique","family":"Nuyt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sainte\u2010Justine Hospital University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Leduc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Audibert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology CHU Sainte\u2010Justine University of Montreal Montreal QC Canada"},{"name":"Department of Obstetrics and Gynecology University of Sherbrooke Sherbrooke Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2719"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150702"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.08.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2718"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.06.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31821c832f"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.11.011"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441781"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500500216546"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2014.09.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03307.x"},{"key":"e_1_2_8_17_1","first-page":"715","article-title":"Report of the Canadian Hypertension Society Consensus Conference: 1. 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