{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:00:28Z","timestamp":1788580828458,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate if a self\u2010obtained vaginal sample (SOVAS) contains sufficient DNA for a human papillomavirus (HPV) test and if the results are comparable to those obtained via cervical samples (CS) collected by a physician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and fifty\u2010one women who had abnormal cervical smears or who were HPV\u2010positive were enrolled. Self\u2010sampling was done after reading instructions and watching a 2\u2010min\u2010long video, whereas CS was obtained with a cervical cytobrush during a gynecologic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A multiplex real\u2010time polymerase chain reaction\u2010based assay detected the prevalence of any type of HPV to be 67.5% in the SOVAS and 57.4% in the CS, and that of high\u2010risk (HR\u2010) HPV to be 58.7% in the SOVAS and 48.6% in the CS. The sensitivity of detection of HR\u2010HPV in the SOVAS was 100% (95% confidence interval [CI] \u20130.09 to 0.32) for high\u2010grade squamous intraepithelial lesion, 78% (95% CI \u20130.09 to 0.13) for atypical squamous cells of undetermined significance or worse, and 95% (95% CI \u20130.01 to 0.25) for low\u2010grade squamous intraepithelial lesion or worse, which was statistically within the non\u2010inferiority margin compared with that of CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that the collection of a SOVAS is feasible and it is comparable to a CS for HPV DNA testing. Future studies are required to investigate the feasibility and cost\u2010effectiveness of a mail\u2010delivered SOVAS for cervical cancer screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13574","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:17:35Z","timestamp":1608866255000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Self\u2010obtained vaginal samples for HPV DNA testing to detect HPV\u2010related cervical disease"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-8147","authenticated-orcid":false,"given":"Moon\u2010Hong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea Institute of Radiological &amp; Medical Sciences Korea Cancer Center Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Jung","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea Institute of Radiological &amp; 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