{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:15:24Z","timestamp":1793171724713,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we investigated the effect of thyroid\u2010stimulating hormone (TSH) level on the outcomes of in vitro fertilization (IVF) in patients with polycystic ovary syndrome (PCOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data pertaining to 60 patients who underwent IVF between May 2017 and May 2018 were included in the study. Thirty\u2010two patients were diagnosed as PCOS (PCOS group) and 28 patients had tubal infertility (control group). Serum and follicular fluid TSH levels and follicular cyclic AMP (cAMP) level were detected by ELISA. TSH receptor (TSHR) expression level in granulosa cells was quantified by RT\u2010PCR and Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the PCOS group, oocyte maturation rate and fertilization rate were significantly lower than in the control group. Serum and follicular fluid TSH levels and ovarian cAMP level were higher in the PCOS group with an upregulation of ovarian TSHR. On multivariate linear regression analysis, fertilization rate showed a negative correlation with TSH levels in serum (B\u00a0=\u00a0\u22120.106, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and follicular fluid (B\u00a0=\u00a0\u22120.107, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In PCOS patients, TSH levels, both in serum and follicular fluid, were negatively correlated with IVF oocyte maturation rate and fertilization rate. The effect of TSH on controlled ovarian hyperstimulated oocyte growth was likely mediated by the TSHR\/cAMP signaling pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13581","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T13:50:27Z","timestamp":1610286627000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Thyroid\u2010stimulating hormone level is negatively associated with fertilization rate in patients with polycystic ovary syndrome undergoing in vitro fertilization"],"prefix":"10.1002","volume":"155","author":[{"given":"Haijie","family":"Gao","sequence":"first","affiliation":[{"name":"Women and Children's Hospital School of Medicine Xiamen University Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University Xiamen Key Laboratory of Genetic Testing Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital School of Medicine Xiamen University Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ji","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital School of Medicine Xiamen University Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital School of Medicine Xiamen University Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Su","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital School of Medicine Xiamen University Xiamen China"},{"name":"Xiamen Key Laboratory of Reproduction and Genetics Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0504-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60276-6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00700"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02120"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00222"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9370-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60091-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348894"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90769-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq162"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.11.017"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2006.06.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.05.028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms052"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0668-6"},{"key":"e_1_2_8_20_1","first-page":"10","article-title":"Thyroid stimulating hormone levels in euthyroid women with polycystic ovary syndrome","volume":"54","author":"Mitkov M","year":"2015","journal-title":"Akush Ginekol"},{"key":"e_1_2_8_21_1","first-page":"679","article-title":"Detection and measurement of thyroid stimulating hormone in human follicular fluid","volume":"39","author":"De Silva M","year":"1994","journal-title":"J Reprod Med"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04330.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1156"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.01.009"}],"container-title":["International Journal of Gynecology &amp; 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