{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:43:24Z","timestamp":1786977804369,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify high\u2010risk HPV (hrHPV) genotypes associated with high\u2010grade vaginal intraepithelial neoplasia (VaIN), and evaluate the efficacy of various treatments for high\u2010grade VaIN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of outcomes among women diagnosed with VaIN after vaginal punch biopsy conducted due to an abnormal Papanicolaou smear or positive test for hrHPV at a hospital in Seoul, Korea, from 2013 to 2018. Logistic regression was used to identify variables associated with abnormal pathologic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 389 women included in the study, 58 were diagnosed with high\u2010grade VaIN, including VaIN stage 2 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a037), VaIN stage 3 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a016), carcinoma in situ of the vagina (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03), and squamous carcinoma of the vagina (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02). In multivariate logistic regression analysis, risk of high\u2010grade VaIN and cancer was higher among women with abnormal cytology (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.47\u20132.47), any hrHPV infection (OR, 8.75; 95% CI, 1.14\u201367.31), HPV16 infection (OR, 5.71; 95% CI, 2.57\u201312.68), or HPV31 infection (OR, 4.37; 95% CI, 1.45\u201313.11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest that infection with hrHPV, especially HPV16 and HPV31, is significantly associated with high\u2010grade VaIN. Regarding treatment modalities, ablative or excisional treatments showed good efficacy against pathologic regression of high\u2010grade VaIN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13583","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T16:12:15Z","timestamp":1610295135000},"page":"227-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Detection of high\u2010risk human papillomavirus infection and treatment of high\u2010grade vaginal intraepithelial neoplasia: A single\u2010institution study"],"prefix":"10.1002","volume":"154","author":[{"given":"Hyun\u2010Woong","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Guro Hospital Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Guro Hospital Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Guro Hospital Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0687"},{"issue":"280","key":"e_1_2_8_3_1","first-page":"1","article-title":"Prevalence of HPV in adults aged 18\u201069: United States, 2011\u20102014","author":"McQuillan G","year":"2017","journal-title":"NCHS Data Brief"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32078"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-005-0022-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31826916c7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.4.232"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167386"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2000.010005382.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2006.09.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0658-OA"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPH4AFSZHU8EKK"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001827"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25384"},{"key":"e_1_2_8_15_1","first-page":"1219","article-title":"Risk factors for the development of vaginal intraepithelial neoplasia","volume":"125","author":"Li H","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_8_16_1","first-page":"286","article-title":"Vulvar and vaginal cancer, vulvar intraepithelial neoplasia 3 and vaginal intraepithelial neoplasia 3: experience of a referral institute","volume":"18","author":"Siegler E","year":"2016","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.07.018"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181f0b69d"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13977"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.04.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24116"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819bd6e0"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.01.030"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.12.020"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2019.30.e20"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.03.017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.46.1.74"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200310000-00011"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00152.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.09.020"}],"container-title":["International Journal of Gynecology &amp; 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