{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:59:13Z","timestamp":1767135553445,"version":"build-2238731810"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2021,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate the efficacy of isosorbide mononitrate (IMN) for stimulating cervical ripening among pregnant women with premature rupture of membranes (PROM) at or post term.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective randomized double\u2010blind, placebo\u2010controlled trial at Kasr El\u2010Ainy Hospital, Cairo, Egypt, from October 2018 to May 2019. Pregnant women at or post term with PROM and unfavorable cervix (Bishop score \u22646) were randomly assigned to receive intra\u2010vaginal IMN (\n n<\/jats:italic>\n \u00a0=\u00a070) or placebo (\n n<\/jats:italic>\n \u00a0=\u00a070) before admission for induction of labor. The main outcome was induction to the delivery interval. Data were compared between groups by\n t<\/jats:italic>\n test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The mean\u00a0\u00b1\u00a0SD duration from the initial dose of IMN\/placebo to the beginning of the active phase of labor was significantly shorter in the IMN group than in the control group (9.7\u00a0\u00b1\u00a05.6\u00a0h vs. 12.9\u00a0\u00b1\u00a05.3\u00a0h). The IMN group also had a shorter time interval from induction to delivery (\n P<\/jats:italic>\n \u00a0<\u00a00.01). There was no difference in adverse effects between the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Intra\u2010vaginal IMN for cervical ripening in the induction of labor among pregnant with PROM at or post term was found to be effective and safe with minimal adverse effects, and good neonatal and maternal outcomes.<\/jats:p>\n \n ClinicalTrials.gov<\/jats:ext-link>\n : NCT03665779.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.13604","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T04:28:58Z","timestamp":1610944138000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED: Isosorbide mononitrate for cervical ripening in induction of labor for pregnant women with PROM at or post term"],"prefix":"10.1002","volume":"155","author":[{"given":"Ahmed N.","family":"Afifi","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Faculty of Medicine Kasr El\u2010Ainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A.","family":"Taymour","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Faculty of Medicine Kasr El\u2010Ainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed M.","family":"El\u2010Khayat","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Faculty of Medicine Kasr El\u2010Ainy Hospital Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026090"},{"issue":"8","key":"e_1_2_8_3_1","first-page":"1","article-title":"Different methods for the induction of labour in outpatient settings","author":"Dowswell 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