{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:54:35Z","timestamp":1785207275485,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the association between cervical polyps in early pregnancy and late abortion and spontaneous preterm birth (SPTB). We also aimed to explore the relationship between cervical polyps and cervical insufficiency in the second trimester.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 2941 singleton pregnant women between January 2010 and December 2015. The frequency of late abortion and SPTB (before 28, 34, or 37\u00a0weeks of pregnancy) was compared between the two groups of 142 (4.8%) patients who had cervical polyps early in the pregnancy (P group) and 2799 who did not (non\u2010P group). Multivariate analysis was performed to identify risk factors for late abortion and SPTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of late abortion and SPTB was significantly higher in the P group than in the non\u2010P group. Cervical polyps in early pregnancy were selected as independent risk factors for late abortion and SPTB before 28, 34, or 37\u00a0weeks of pregnancy. The P group had a significantly higher rate of cases requiring therapeutic cervical cerclage than the non\u2010P group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cervical polyps in early pregnancy are risk factors for late abortion and SPTB. They are also associated with the occurrence of cervical insufficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13608","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T09:57:41Z","timestamp":1611136661000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cervical polyps in early pregnancy are a risk factor for late abortion and spontaneous preterm birth: A retrospective cohort study"],"prefix":"10.1002","volume":"156","author":[{"given":"Emi","family":"Hirayama","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-7546","authenticated-orcid":false,"given":"Yasuhiko","family":"Ebina","sequence":"additional","affiliation":[{"name":"Division of Comprehensive Development Nursing Faculty of Health Sciences Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinuko","family":"Akabane\u2010Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo City General Hospital Sapporo Japan"},{"name":"Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo City General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)36314-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.04.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2710-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.942633"},{"key":"e_1_2_8_7_1","first-page":"92","article-title":"Standardization of fetal ultrasound measurements and Japanese reference values","volume":"57","author":"Perinatal Committee","year":"2005","journal-title":"Nihon Sanka Fujinka Gakkai zasshi"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12120"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12786"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2100"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.01.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512283332604"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000443276.68274.cc"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422007"},{"key":"e_1_2_8_15_1","first-page":"227","article-title":"The role of matrix metalloproteinases for premature rupture of the membranes","volume":"45","author":"So T","year":"1993","journal-title":"Nihon Sanka Fujinka Gakkai zasshi"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349109006174"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0948"},{"key":"e_1_2_8_18_1","first-page":"26","article-title":"The relation between granulocyte elastase activity in cervical mucus and gestational cervical polyp","volume":"43","author":"Kanayama N","year":"1991","journal-title":"Nihon Sanka Fujinka Gakkai zasshi"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2007.0408"},{"key":"e_1_2_8_20_1","first-page":"20","article-title":"Decidual ectopy on the uterine cervix. 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