{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:16:02Z","timestamp":1785208562308,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To conduct a clinical trial to investigate the effect of\n                      <jats:italic>N<\/jats:italic>\n                      \u2010acetyl cysteine (NAC), a non\u2010hormonal drug, on the volume of leiomyoma, the most common benign tumor in women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study is a randomized clinical trial, which was performed in Semnan, Iran. Eligible women who were diagnosed with uterine leiomyoma using vaginal ultrasound were randomly assigned to receive NAC or placebo for 12 weeks. The change in the volume of Leiomyoma was considered to be the main variable in the efficacy evaluation. Reduction in the leiomyoma volume was calculated after intervention and data were entered in SPSS version 23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty individuals were enrolled in our study. 25 women received NAC, while 25 women took placebo. The mean volume of leiomyoma in group A was 5.71 cm\n                      <jats:sup>3<\/jats:sup>\n                      and in group B was 6.56 cm\n                      <jats:sup>3<\/jats:sup>\n                      . The mean rate of volume reduction in the A and B groups was 25.25 % and 1.08 %, respectively, which demonstrated a significant difference between the two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although this trial recommends the use of NAC as a non\u2010hormonal drug in the treatment of leiomyoma of the uterus, the possibility of treatment failure in controlling abnormal uterine bleeding cannot be ignored. Nevertheless, we can say it is feasible and effective in the reduction of leiomyoma volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13611","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T21:39:12Z","timestamp":1611265152000},"page":"521-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of\n                    <i>N<\/i>\n                    \u2010acetyl cysteine on the volume of uterine leiomyoma: A randomized clinical trial"],"prefix":"10.1002","volume":"154","author":[{"given":"Shahrzad","family":"Aghaamoo","sequence":"first","affiliation":[{"name":"Gynecology Department Faculty of Medicine Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azade","family":"Zandbina","sequence":"additional","affiliation":[{"name":"Gynecology Department Faculty of Medicine Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Saffarieh","sequence":"additional","affiliation":[{"name":"Gynecology Department Faculty of Medicine Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6900-7345","authenticated-orcid":false,"given":"Setare","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Endometriosis Research Center, Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880055"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2018.1417381"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"41","article-title":"Uterine fibroids: from observational epidemiology to clinical management","volume":"84","author":"Vercellini P","year":"2017","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"1503","article-title":"Uterine fibroid tumors: diagnosis and treatment","volume":"75","author":"Evans P","year":"2007","journal-title":"Am Fam Physician"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"129","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"83","author":"Stewart EA","year":"2017","journal-title":"J Obstet Gynaecol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01900-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5787"},{"issue":"5","key":"e_1_2_8_9_1","article-title":"Growth of uterine leiomyomata among premenopausal black and white women","volume":"105","author":"Peddada SD","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)03622\u20109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891x.2005.15016.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.17116\/repro20202605151"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"67","article-title":"Change in proliferating and apoptotic markers of leiomyoma following treatment with a selective progesterone receptor modulator or gonadotropin\u2010releasing hormone agonist","volume":"191","author":"Yun BS","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.04.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.09.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(67)90090-1"},{"issue":"2","key":"e_1_2_8_17_1","first-page":"116","article-title":"Study of the protective effect of N\u2010acetyl cysteine against acute diazinon\u2010induced oxidative stress in rat brain and heart","volume":"15","author":"Tahmasebi K","year":"2015","journal-title":"J Ardabil Univ Med Sci"},{"key":"e_1_2_8_18_1","unstructured":"Cumberland Pharmaceuticals IncDailyMed.2013. 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