{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T13:49:38Z","timestamp":1766497778390,"version":"3.48.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate if high\u2010dose letrozole can be used successfully to stimulate poor responders for in vitro fertilization (IVF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study conducted at a university hospital reproductive center. The analysis included women who were up to 42\u00a0years of age and were Rotterdam Consensus poor responders. A total of 247 patients received gonadotropins (300\u2013450\u00a0IU daily) and 62 patients were stimulated with letrozole (20\u00a0mg daily) as part of an antagonist IVF protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The use of 20\u00a0mg of letrozole decreased the total dose of gonadotropins used (645\u00a0\u00b1\u00a0175\u00a0IU vs. 5360\u00a0\u00b1\u00a01028\u00a0IU,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001) and resulted in lower costs of stimulation medications ($\u00a0555.56\u00a0\u00b1\u00a0$\u00a0150 vs. $\u00a04616\u00a0\u00b1\u00a0$\u00a0885 Canadian Dollars;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001). Pregnancy per cycle (14.5%) and per transfer (16%) rates were legitimate for this low prognosis group and may have been better than or similar to those with high\u2010dose gonadotropins. The rate of cycle cancellation may have been reduced in the letrozole versus gonadotropin group (11% vs. 38%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Letrozole (20\u00a0mg daily) may be used to reduce the cost of ovarian stimulation in ultra\u2010poor responders, significantly reducing the cost of the IVF cycle with probably at least similar outcomes to high\u2010dose gonadotropins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13626","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:08:56Z","timestamp":1611864536000},"page":"102-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of in vitro fertilization cycles stimulated with 20\u00a0mg letrozole daily versus high\u2010dose gonadotropins in Rotterdam Consensus ultra\u2010poor responders: A proof of concept"],"prefix":"10.1002","volume":"156","author":[{"given":"Mohammad","family":"Khojah","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University Montreal QC Canada"},{"name":"Division of Reproductive Endocrinology and Infertility MUHC Reproductive Center McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhaib","family":"Khayat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University Montreal QC Canada"},{"name":"Division of Reproductive Endocrinology and Infertility MUHC Reproductive Center McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Dahan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology McGill University Montreal QC Canada"},{"name":"Division of Reproductive Endocrinology and Infertility MUHC Reproductive Center McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.730569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.05.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev198"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.07.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjod.80090"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0227-y"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der092"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejogrb.2013.10.027","article-title":"A comparison of outcomes from in vitro fertilization cycles stimulated with either recombinant luteinizing hormone (LH) or human chorionic gonadotropin acting as an LH analogue delivered as human menopausal gonadotropins, in subjects with good or poor ovarian reserve: a retrospective analysis","volume":"172","author":"Dahan MH","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.036"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.01.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1391202"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0288-8"}],"container-title":["International Journal of Gynecology &amp; 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