{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T21:11:17Z","timestamp":1764969077628,"version":"3.46.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the impact of lymphadenectomy on the prognosis of women of reproductive age with clinically apparent Stage I epithelial ovarian cancer (EOC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of women of reproductive age with Stage I EOC, diagnosed between 2010 and 2016, were extracted from the Surveillance, Epidemiology, and End Results database. Five\u2010year cancer\u2010specific survival (CSS) was evaluated using the Kaplan\u2013Meier method. Multivariate Cox analysis was performed to evaluate the effect of lymph node dissection on survival. Propensity score (PS) matching was conducted to balance various clinicopathologic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 2222 patients included, 1609 (72.4%) received lymph node dissection. The rate of histopathologically confirmed lymph node metastasis was highest in serous subtype (10.2%) and lowest in mucinous subtype (2.2%). No significant difference between the lymphadenectomy and non\u2010lymphadenectomy groups in 5\u2010year CSS was observed in the original cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.364) or in the PS matching cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.248). Nevertheless, there was a significant difference between the lymphadenectomy and non\u2010lymphadenectomy groups for patients with Stage IC EOC (92.4% vs. 88.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.027). According to the multivariate analysis, performance of the lymphadenectomy was not significantly associated with CSS in the original cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.163) or the PS matching cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.101).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dissection of lymph nodes was not significantly associated with improved prognosis for most Stage I EOC, but, lymphadenectomy may be necessary for women of reproductive age with Stage IC subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13627","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:08:55Z","timestamp":1611864535000},"page":"550-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of lymph node dissection on apparent Stage I epithelial ovarian carcinoma: A population\u2010based study"],"prefix":"10.1002","volume":"154","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; 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