{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:19:43Z","timestamp":1790047183035,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish trimester\u2010specific reference intervals (TSRIs) for blood lipid profiles in Chinese women and explore their associations with pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were women with singleton pregnancies aged 18\u201345\u00a0years without pre\u2010existing chronic diseases who delivered from January 2018 to December 2018 from an ongoing cohort in Beijing, China. Baseline information and pregnancy outcomes were from the medical records. Blood lipid levels were measured at 7\u201313, 24\u201328, and 32\u201334\u00a0weeks of pregnancy. We estimated TSRIs for lipid profiles using an indirect Hoffmann method and evaluated their associations with pregnancy outcomes, including gestational diabetes, pregnancy\u2010induced hypertension, macrosomia, low birth weight, large or small for gestational age, and preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The established TSRIs were 3.21\u20135.38, 4.64\u20137.56, and 4.86\u20138.20\u00a0mmol\/L for total cholesterol; 0.37\u20131.81, 1.14\u20133.49, and 1.61\u20134.63\u00a0mmol\/L for triglycerides; 1.12\u20132.19, 1.33\u20132.49, and 1.24\u00a02.31\u00a0mmol\/L for high\u2010density lipoprotein cholesterol; 1.33\u20132.98,1.97\u20134.36, and 2.02\u20134.92\u00a0mmol\/L for low\u2010density lipoprotein cholesterol from first trimeseter to third trimester, respectively. Both higher and lower levels of lipid profiles than TSRIs were associated with adverse pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggested TSRIs for blood lipid levels in a Chinese population. Inappropriate lipid levels were associated with adverse pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13636","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T09:59:26Z","timestamp":1612605566000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Establishing reference ranges of serum lipid level during pregnancy and evaluating its association with perinatal outcomes: A cohort study"],"prefix":"10.1002","volume":"156","author":[{"given":"Wei","family":"Zheng","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Endotext [Internet]","author":"Grimes SB","year":"2000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:19:1:43"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12693"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094594"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0852-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.191"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01372"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2018.09.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.025"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.08.007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90190-A"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPN5BMTSF1CDYP"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22344"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2750-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1295"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12742"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90107-7"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0885-3"},{"key":"e_1_2_9_22_1","volume-title":"Williams Obstetrics\u201424th Edition","author":"Gary Cunningham F","year":"2014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117746785"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060110068020"}],"container-title":["International Journal of Gynecology &amp; 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