{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:14:14Z","timestamp":1781558054243,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the role and benefits of transcervical fibroid ablation (TFA) in the treatment of submucous and large uterine fibroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A subgroup of patients with submucous or large fibroids were analyzed from two prospective clinical trials (FAST\u2010EU and SONATA) of sonography\u2010guided TFA with the Sonata<jats:sup>\u00ae<\/jats:sup> system. Key outcomes were changes in menstrual blood loss, symptom severity and health\u2010related quality of life on the Uterine Fibroid Symptom and Quality\u2010of\u2010Life Questionnaire, health\u2010related quality of life on the EQ\u20105D questionnaire, and surgical reinterventions for heavy menstrual bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 197 women (534 treated fibroids), 86% of women with only submucous fibroids and 81% of women with large fibroids (&gt;5\u00a0cm) experienced bleeding reduction within 3\u00a0months post\u2010ablation. Overall symptom severity and health\u2010related quality of life showed sustained, significant improvements over 12\u00a0months. Additional fibroid mapping of large fibroids with magnetic resonance imaging in the FAST\u2010EU trial showed an average volume reduction of 68%. Among women with only submucous fibroids, the rate of surgical reintervention through 1\u00a0year of follow up was 3.7% in FAST\u2010EU and 0.0% in SONATA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With the Sonata system, TFA is an effective single\u2010stage treatment option for non\u2010pedunculated submucous myomata, and larger or deeper uterine fibroids (including fibroid clusters) for which hysteroscopic treatment is not suitable.<\/jats:p><jats:p><jats:bold>ClinicalTrials.gov:<\/jats:bold> FAST\u2010EU, NCT01226290; SONATA, NCT02228174.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13638","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T19:16:36Z","timestamp":1612552596000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcervical fibroid ablation with the Sonata\u2122 system for treatment of submucous and large uterine fibroids"],"prefix":"10.1002","volume":"155","author":[{"given":"Gregory","family":"Shifrin","sequence":"first","affiliation":[{"name":"Surgery of Tomorrow ASC Brooklyn NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Department of Gynecology Josephs\u2010Hospital Warendorf Warendorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Gee","sequence":"additional","affiliation":[{"name":"Willowbend Health and Wellness Frisco TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Pschadka","sequence":"additional","affiliation":[{"name":"Department of Gynecology Josephs\u2010Hospital Warendorf Warendorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.11.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-199508000-00015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199011000-00023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.01.014"},{"issue":"5","key":"e_1_2_8_7_1","first-page":"743","article-title":"Long\u2010term results of hysteroscopic myomectomy for abnormal uterine bleeding","volume":"93","author":"Emanuel MH","year":"1999","journal-title":"Obstet Gynecol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2014.08.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-015-0915-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003032"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2019.0012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-017-0194-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-014-0873-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-010-0655-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2020.0021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-99"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(00)80032-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)80013-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2010.526098"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.09.013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009363"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200008000-00021"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2017.6752"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200303000-00005"}],"container-title":["International Journal of Gynecology &amp; 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