{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:34:12Z","timestamp":1792593252377,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sepsis is a leading cause of maternal death. Antimicrobials save lives, but inappropriate overuse increases risk of antimicrobial resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>A scoping review comparing peripartum prophylactic antimicrobial use in low\u2010 and middle\u2010income countries (LMICs) with WHO recommendations for prevention and treatment of maternal peripartum infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Medline, Embase, Global Health, LILACS and the WHO Library databases were searched.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Publications from LMICs since 2015 describing maternal prophlyactic antibiotics for group B streptococcus (GBS), preterm\u2010prelabor rupture of membranes (PPROM), cesarean section, manual placental removal, and third\/fourth\u2010degree perineal tears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Publications were screened, and duplicates were removed. A scoping review was conducted using PRISMA guidelines. Owing to study heterogeneity, a narrative synthesis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Of 1886 studies, 27 studies from 13 countries involving 43\u00a0774 women met the eligibility criteria. Polymerase chain reaction screening for GBS is feasible, though limited financially. In PPROM, up to 42% of GBS isolates demonstrated erythromycin resistance. Evidence around cesarean section antimicrobial prophylaxis largely supports WHO recommendations; however, prolonged or multidrug regimens were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is limited evidence to challenge current WHO recommendations to prevent peripartum infection in LMICs. However, implementation challenges exist. Given the emergence of antimicrobial resistance, research is needed to ensure that peripartum prophylactic antimicrobial choices remain effective.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13648","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T09:02:58Z","timestamp":1613811778000},"page":"319-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A scoping review of maternal antibiotic prophylaxis in low\u2010 and middle\u2010income countries: Comparison to WHO recommendations for prevention and treatment of maternal peripartum infection"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-3880","authenticated-orcid":false,"given":"Imogen","family":"Jury","sequence":"first","affiliation":[{"name":"Medical Sciences Division University of Oxford Medical School Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Thompson","sequence":"additional","affiliation":[{"name":"Global Women\u2019s Health Program The George Institute for Global Health Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Hirst","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women\u2019s &amp; Reproductive Health University of Oxford Oxford UK"},{"name":"The George Institute for Global Health Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Statement on maternal sepsis;2017.https:\/\/www.who.int\/reproductivehealth\/publications\/maternal_perinatal_health\/maternalsepsis\u2010statement\/en\/"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31533-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-017-0437-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12646"},{"key":"e_1_2_7_6_1","first-page":"80","article-title":"WHO recommendations for prevention and treatment of maternal peripartum infections","author":"WHO","year":"2015","journal-title":"World Health Organisation"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3402\/gha.v9.33381"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2011.0358"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_7_10_1","unstructured":"WHO.WHO library and digital information networks.2020.https:\/\/www.who.int\/tb\/publications\/library_database\/en\/"},{"key":"e_1_2_7_11_1","unstructured":"Rayyan QCRI.the Systematic Reviews web app.https:\/\/rayyan.qcri.org\/welcome. 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