{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:47:04Z","timestamp":1785577624393,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T00:00:00Z","timestamp":1617494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare three types of biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Postmenopausal women undergoing operative hysteroscopy with endometrial biopsy for abnormal uterine bleeding or endometrial thickness (\u22655\u00a0mm) were included. Operative hysteroscopy with endometrial biopsy was performed by hysteroscopic forceps. Women were randomized (1:1:1 ratio) in three groups and allocated to undergo endometrial biopsy by hysteroscopy using spoon, alligator, or snake forceps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five women were included in the study, 25 in each group. The duration of the biopsy was comparable between the three groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.334) with a median of 180 seconds (range 20\u2013480 seconds). No differences were observed about the number of attempts (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.602), the use of another instrument (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.276), and the biopsy appropriateness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.592). The spoon forceps group reported higher levels of pain compared to the alligator and snake forceps groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The spoon forceps received significantly lower scores by the operator compared to the alligator and snake forceps (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The alligator and snake forceps reported wider biopsy than the spoon forceps (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Snake and alligator hysteroscopic forceps may be considered the first choice to perform an endometrial biopsy in postmenopausal women.<\/jats:p><jats:p>ClinicalTrials.gov: NCT03427957.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13669","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T04:29:38Z","timestamp":1615264178000},"page":"425-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Comparison of three biopsy forceps for hysteroscopic endometrial biopsy in postmenopausal patients (HYGREB\u20101): A multicenter, single\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"155","author":[{"given":"Salvatore Giovanni","family":"Vitale","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Unit Department of General Surgery and Medical Surgical Specialties University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u201cFilippo Del Ponte\u201d Hospital University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Caruso","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit Department of General Surgery and Medical Surgical Specialties University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u201cFilippo Del Ponte\u201d Hospital University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada Maria","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies \u201cG.F. Ingrassia,\u201d Anatomic Pathology School of Medicine University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Lucia","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Unit of Psychodiagnostics and Clinical Psychology University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jvan","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u201cFilippo Del Ponte\u201d Hospital University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u201cFilippo Del Ponte\u201d Hospital University of Insubria Varese Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2010.07.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.13.1610"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg465"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6848250"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.09.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349.2010.499444"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2019.1625404"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2019.1576054"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00400.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-014-0627-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.6.468"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2053369118755190"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57559-9_2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-3-201302050-00583"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.12.014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(85)90045-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2015.01.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2015.11.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1258\/mi.2010.010008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443619750112989"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6256"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.12.118"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.01.019"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-032304101-0.50013-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.029702"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T09:56:09Z","timestamp":1715421369000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,4]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ijgo.13669"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13669","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,4]]},"assertion":[{"value":"2020-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}