{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:18:19Z","timestamp":1775481499809,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pre\u2010eclampsia and delivery of small\u2010for\u2010gestational\u2010age (SGA) neonates can be predicted from the first trimester. A Gaussian model for prediction of PE has recently been described, although its capacity to predict SGA is still unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a secondary analysis of a prospective cohort study conducted at Vall d\u2019Hebron University Hospital (Barcelona) in 2483 single pregnancies from October 2015 to September 2017. Mean arterial blood pressure and mean uterine artery pulsatility index were recorded at the first\u2010trimester scan. Serum concentrations of placental growth factor and pregnancy\u2010associated plasma protein\u2010A were assessed between 8<jats:sup>+0<\/jats:sup> and 13<jats:sup>+6<\/jats:sup>\u00a0weeks. The predictive capacities of early (&lt;32\u00a0weeks) and preterm (&lt;37\u00a0weeks) SGA were tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For SGA without pre\u2010eclampsia, detection rates of 25.0% (95% confidence interval [CI] 0\u201375.0) for early SGA and 14.3% (95% CI 3.6\u201328.6) for preterm SGA were achieved. For SGA with pre\u2010eclampsia, the algorithm showed detection rates of 100.0% (95% CI 25.0\u2013100.0) for early SGA and 56.3% (95% CI 31.3\u201381.3) for preterm SGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This algorithm identifies 62.5% of early SGA and 27.3% of preterm SGA. Combined screening for predicting both pre\u2010eclampsia and SGA by using the Gaussian algorithm is feasible and would simplify clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13673","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T12:26:01Z","timestamp":1615897561000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic accuracy of the Gaussian first\u2010trimester combined screening for pre\u2010eclampsia to predict small\u2010for\u2010gestational\u2010age neonates"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3030-3833","authenticated-orcid":false,"given":"Manel","family":"Mendoza","sequence":"first","affiliation":[{"name":"Maternal Fetal Medicine Unit Department of Obstetrics Hospital Universitari Vall d\u2019Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona 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