{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:25:00Z","timestamp":1792686300571,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["96.03.345"],"award-info":[{"award-number":["96.03.345"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effects of dienogest and a combined oral contraceptive pill (COCP) after laparoscopic surgery on pain and quality of life in women with severe endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized double\u2010blind pilot study was conducted from March 2018 to March 2020 in women with severe endometriosis confirmed by laparoscopic surgery. A total of 108 patients who had undergone laparoscopic surgery received dienogest, COCP, or placebo daily for 6\u00a0months. Primary and secondary outcomes were compared between the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment with dienogest or COCP was associated with improved self\u2010reported pain after 6\u00a0months of treatment, as evidenced by significantly lower scores for pelvic pain and dyspareunia compared with placebo (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Significant differences in overall quality of life score were observed over 6\u00a0months in the dienogest, COCP, and placebo groups (mean difference 22.00, 23.45, and 6.45 points, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Post\u2010hoc analysis revealed a significant difference in overall quality of life score between the placebo group and the dienogest (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and COCP groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postoperative administration of dienogest or COCP reduced endometriosis\u2010associated pain and improved quality of life in women with severe endometriosis.<\/jats:p>\n                    <jats:p>\n                      Clinical trials registration:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.irct.ir\/trial\/43070\">https:\/\/en.irct.ir\/trial\/43070<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13677","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T04:02:02Z","timestamp":1615953722000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A randomized, double\u2010blind, placebo\u2010controlled pilot study of the comparative effects of dienogest and the combined oral contraceptive pill in women with endometriosis"],"prefix":"10.1002","volume":"156","author":[{"given":"Abolfazl","family":"Mehdizadeh Kashi","sequence":"first","affiliation":[{"name":"Endometriosis Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Niakan","sequence":"additional","affiliation":[{"name":"School of Medicine Iran University of Medical Sciences Tehran 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