{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:18:01Z","timestamp":1790306281355,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore treatment strategies for patients with positive margins after cervical cold knife conization (CKC) by estimating the risk of residual or recurrent CIN2 or worse (CIN2+).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study included 569 patients receiving CKC for CIN3 in Xiangya Hospital from January 2013 to December 2017. Demographic characteristics and test results were obtained before CKC, after CKC, at 6, 12, and 24\u00a0months, then annually thereafter. The primary end point was residual\/recurrent CIN2+ post\u2010CKC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen (2.46%) patients had residual\/recurrent CIN2+ with a median time of occurrence at 12\u00a0months post\u2010CKC. Taking the average age and hrHPV viral load tested by Hybrid Capture 2 (HC2) as thresholds, the risk of residual\/recurrent CIN2+ was higher in women aged over 40\u00a0years or with a baseline HC2 of 300 or more for the ratio of relative light units to positive cut\u2010off values. Patients with positive margins were at higher risk of residual\/recurrent CIN2+ (hazard ratio 3.66, 95% confidence interval 1.25\u201310.71), especially when endocervix was involved. A total of 536 (94.20%) patients received HPV testing within 6\u00a0months after CKC. Patients with both positive HPV testing results and positive margins were at the highest risk of residual\/recurrent CIN2+.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with positive endocervical margins are at high risk for residual\/recurrent CIN2+, independent of the severity of margins. HPV testing within 6\u00a0months after CKC may be a feasible triage strategy for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13683","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T23:50:38Z","timestamp":1616543438000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The treatment strategy of patients with positive margins after cervical cold knife conization\u2014A 7\u2010year retrospective study in China"],"prefix":"10.1002","volume":"156","author":[{"given":"Kun","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Gynecology Xiangya Hospital Central South University Changsha China"},{"name":"Gynecological Oncology Research and Engineering Center of Hunan Province Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 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