{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:41:14Z","timestamp":1778676074945,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>On May 13, 2020, the Italian government Pharmaceutical Agency (AIFA) stopped ulipristal acetate (UPA) treatments for uterine fibroids (UFs), so patients shifted to other natural treatments. The authors tested the patients\u2019 compliance with UF natural treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty patients of reproductive age (30\u201345\u00a0years) affected by UFs stopped UPA intake and started epigallocatechin gallate (EGCG) plus vitamin D3 treatment. Patients were asked to complete the Uterine Fibroid symptoms and Quality of Life (UFS\u2010QOL) questionnaire, divided into symptoms severity (SS) and health\u2010related quality of life (HRQL), after UPA suspension and to repeat it after 3\u00a0months of natural treatment. Collected data were analyzed using paired Student's\n                      <jats:italic>t<\/jats:italic>\n                      test, considering a\n                      <jats:italic>P<\/jats:italic>\n                      value less than 0.05 to be significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SS score was significantly lower (\u201312.19%) for natural treatment when compared with UPA administration. The HRQL score significantly improved (+11.79%) after shifting treatment from UPA to natural therapy. All the investigated parameters appeared improved by 10% after the natural treatment. No adverse effects were reported following the natural treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Natural treatments showed positive compliance in patients with UFs, based on HRQL score, representing an alternative therapeutic opportunity for patients forced to stop UPA therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13692","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T08:26:02Z","timestamp":1617351962000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nutraceuticals in fibroid management after ulipristal acetate administration: An observational study on patients\u2019 compliance"],"prefix":"10.1002","volume":"156","author":[{"given":"Andrea","family":"Tinelli","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"},{"name":"CERICSAL (CEntro di RIcerca Clinico SALentino \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"},{"name":"Division of Experimental Endoscopic Surgery, Imaging, Technology and Minimally Invasive Therapy Vito Fazzi Hospital Lecce Italy"},{"name":"Laboratory of Human Physiology Phystech BioMed School Faculty of Biological &amp; Medical Physics Moscow Institute of Physics and Technology (State University) Dolgoprudny Moscow Region Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Gustapane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavia","family":"D\u2019Oria","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Licchelli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Panese","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology \u201cVeris delli Ponti Hospital\u201d Scorrano (Le) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"424","article-title":"Epidemiology of uterine myomas","volume":"9","author":"Sparic R","year":"2016","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599090"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1209993"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808188105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3237"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1251477"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S51083"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.43"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.09.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200121141533"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186158"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.02.008"},{"key":"e_1_2_8_16_1","volume-title":"European Medicine Agency. Assessment reports on provisional measures [EMA website]","year":"2018"},{"key":"e_1_2_8_17_1","unstructured":"Agenzia Italiana del Farmaco.Sospensione di Ulipristal Acetato usato per fibromi uterini durante la revisione in corso dell\u2019EMA sul rischio di danno epatico [AIFA website]2020.https:\/\/www.aifa.gov.it\/documents\/20142\/847374\/2020.03.13_IT_Ulipristal_acetate_com\u2010EMA.pdfAccessed November 27 2020."},{"key":"e_1_2_8_18_1","unstructured":"European Medicine Agency.PRAC recommends revoking marketing authorization of ulipristal acetate for uterine fibroids [EMA website]2020.https:\/\/www.ema.europa.eu\/en\/documents\/referral\/ulipristal\u2010acetate\u20105mg\u2010medicinal\u2010products\u2010article\u201031\u2010referral\u2010prac\u2010recommends\u2010revoking\u2010marketing_en.pdfAccessed November 4 2020."},{"issue":"5","key":"e_1_2_8_19_1","first-page":"477","article-title":"Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study","volume":"7","author":"Roshdy E","year":"2013","journal-title":"Int J Women Health"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005698"},{"key":"e_1_2_8_21_1","first-page":"3344","article-title":"Vitamin D plus epigallocatechin gallate: a novel promising approach for uterine myomas","volume":"24","author":"Porcaro G","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200202000-00021"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.07.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003211"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.885"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0721-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01870.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu4111679"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/214836"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.05.007"},{"key":"e_1_2_8_31_1","first-page":"93","article-title":"Serum Vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross\u2010sectional observational study","volume":"5","author":"Sabry M","year":"2013","journal-title":"Int J Women Health"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.13692","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.13692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T13:34:48Z","timestamp":1766496888000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.13692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ijgo.13692"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.13692","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"assertion":[{"value":"2021-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}