{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:40:11Z","timestamp":1778852411306,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270715"],"award-info":[{"award-number":["81270715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302295"],"award-info":[{"award-number":["81302295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare endometrial receptivity in patients with and without unexplained recurrent implantation failure (URIF) and the benefits of low\u2010dose aspirin treatment in women with URIF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted at Ren Ji Hospital, Shanghai, from January 2014 to January 2017. Endometrial thickness, pulsatility index (PI), resistive index (RI), and systolic\u2010to\u2010diastolic ratio (S\/D) values of endometrial and uterine perfusion were recorded and compared between women with and without URIF. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive accuracy of the risk of URIF. Ultrasonography examination was repeated after 2\u00a0months of treatment with low\u2010dose aspirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PI, RI, and S\/D values for endometrial blood flow were significantly higher in URIF patients than the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The predictive indexes were 0.833, 0.857, and 0.839, respectively. Differences between the groups for endometrial thickness and impedance of uterine perfusion were not significant (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). After low\u2010dose aspirin treatment, endometrial and uterine arterial blood flow resistance in URIF patients was significantly lower than before treatment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>URIF patients had inappropriate endometrial blood flow. Doppler parameters are promising for predicting women at high risk of URIF. Low\u2010dose aspirin treatment can improve endometrial receptivity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13699","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T08:10:27Z","timestamp":1617869427000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low\u2010dose aspirin treatment improves endometrial receptivity in the midluteal phase in unexplained recurrent implantation failure"],"prefix":"10.1002","volume":"156","author":[{"given":"Xiaoxin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai JiaoTong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai JiaoTong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai JiaoTong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai JiaoTong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8022-5175","authenticated-orcid":false,"given":"Aimin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai JiaoTong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23174"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0414-2"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"1","article-title":"Evidence\u2010based update: immunological evaluation of recurrent implantation failure","volume":"1","author":"Comins\u2010Boo A","year":"2016","journal-title":"J Reprod Immunol Open Acc"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.165153"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513599009024978"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54848-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009474307376"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.6.453"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.02.082"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.01020"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00088-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.06030191.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138366"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2007.07.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000175362.12470.e0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh056"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58082-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60428-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.5.1146"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00088-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007720"},{"issue":"3","key":"e_1_2_8_25_1","first-page":"327","article-title":"Production of prostacyclin and thromboxane in lupus pregnancies: effect of small dose of aspirin","volume":"81","author":"Kaaja R","year":"1993","journal-title":"Obstet Gynecol"}],"container-title":["International Journal of Gynecology &amp; 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