{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:21:14Z","timestamp":1791418874988,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Besides reducing the quality of obstetric care, the direct impact of COVID\u201019 on pregnancy and postpartum is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the characteristics of pregnant women who died due to COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Cochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Studies that compared deceased and survived pregnant women with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Relevant data were extracted and tabulated. The primary outcome was maternal co\u2010morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Thirteen studies with 154 deceased patients were included. Obesity doubled the risk of death (relative risk [RR] 2.48, 95% confidence interval [CI] 1.41\u20134.36, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%). No differences were found for gestational diabetes (RR 5.71; 95% CI 0.77\u201342.44, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a094%) or asthma (RR 2.05, 95% CI 0.81\u20135.15, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%). Overall, at least one severe co\u2010morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77\u20132.89, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a076%). Admission to intensive care was related to a fivefold increased risk of death (RR 5.09, 95% CI 2.00\u201312.98, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a056%), with no difference in need for respiratory support (RR 0.53, 95% CI 0.23\u20131.48, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a095%) or mechanical ventilation (RR 4.34, 95% CI 0.96\u201319.60, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a058%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 with at least one co\u2010morbidity increases risk of intensive care and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13726","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T18:58:43Z","timestamp":1619809123000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Maternal death related to COVID\u201019: A systematic review and meta\u2010analysis focused on maternal co\u2010morbidities and clinical characteristics"],"prefix":"10.1002","volume":"154","author":[{"given":"Marco","family":"La Verde","sequence":"first","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Riemma","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Torella","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit University of Campania \u201cLuigi Vanvitelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cianci","sequence":"additional","affiliation":[{"name":"Dipartimento di Ginecologia Oncologica e Chirurgia Ginecologica Miniinvasiva Policlinico G. 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