{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:45Z","timestamp":1747149285983,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the perioperative outcomes and complications of patients with peritoneal carcinomatosis who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 100 patients operated on between 2016 and 2020. Patients\u2019 characteristics, including age, comorbidities, chemotherapy history, treatment failures, cancer type, histology, platinum sensitivity, and perioperative complications, were documented. Perioperative complications were classified according to the Clavien\u2010Dindo classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 58\u00a0years and median follow\u2010up time was 16\u00a0months. Eighty\u2010six (86%) patients had ovarian cancer; 11 (11%) experienced grade III\u2013IV complications, and the only relevant factor was the presence of multiple metastasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031). Seven patients (7%) had surgical\u2010site infection; in multivariant analyses, only ostomy formation was found as an independent risk factor for surgical\u2010site infection (odds ratio [OR] 14.01; 95% confidence interval [CI] 1.36\u2013143.52; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.024). Fifteen (15%) patients experienced elevated serum creatinine after surgery and the median time to creatinine elevation was 5\u00a0days postoperatively (range 3\u201315\u00a0days). In multivariant analyses, only age of of 58\u00a0years or more was found as a significant factor for the elevation of serum creatinine (OR 6.96; 95% CI 1.42\u201332.81; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that the presence of multiple metastases increased the risk of grade III\u2013IV complications and age of 58\u00a0years or more was the leading risk factor for renal complications. However, we could not find a relation between postoperative complications and oncologic outcomes. HIPEC seems to be a safe approach in experienced hands.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13767","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T15:41:46Z","timestamp":1622043706000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Complications of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: An evaluation of 100 cases"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-8441","authenticated-orcid":false,"given":"Huseyin","family":"Akilli","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Gunakan","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Haberal","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozden","family":"Altundag","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulku Esra","family":"Kuscu","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cagatay","family":"Taskiran","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Koc University School of Medicine  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics and Gynecology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4157-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21083"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.072"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000664"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.09.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1367846"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2853-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000149"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08843-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.03.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00091"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.03.004"},{"key":"e_1_2_7_17_1","first-page":"1363","article-title":"Hyperthermic intraperitoneal chemotherapy in ovarian cancer","volume":"378","author":"Driel WJ","year":"2018","journal-title":"N Engl J Med"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33167"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-5050-x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13410"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.01.018"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9429-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07964-x"}],"container-title":["International Journal of Gynecology &amp; 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