{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:49:41Z","timestamp":1769633381621,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between mild congenital pulmonary airway malformation (CPAM) and its long\u2010term prognosis in childhood and to explore whether surgery is necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort of fetuses with mild CPAM diagnosed prenatally with available long\u2010term outcomes in childhood from 2004 to 2016. The patients were divided into two groups according to the fetal CPAM\u2010to\u2010volume ratio (CVR) of less than 1.0 and 1.0\u20131.6. The primary outcome was a postnatal composite outcome including CPAM\u2010associated respiratory symptoms and surgical resection of the lesion. The secondary outcomes included neonatal asphyxia, perinatal morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two fetuses were identified as having CVR &lt;1.0 or CVR\u20101.0\u20131.6 respectively (<jats:italic>n<\/jats:italic>\u00a0=\u00a037 vs <jats:italic>n<\/jats:italic>\u00a0=\u00a05; 88.1% vs 11.9%), with the median duration of follow up 2.15\u00a0years (0.3\u201310.8\u00a0years). Of 42 patients, 32 (76%) remained asymptomatic without recurrent respiratory symptoms or surgical resection; the other 10 with CVR &lt;1.0 had respiratory symptoms. Of 10 symptomatic cases, five recovered after expectant treatment, and five underwent resection, for an increase in lesion size and recurrent respiratory infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CVR &lt;1.0 still need to be closely observed after birth. Conservative management is a reasonable option in asymptomatic cases, but surgery might be necessary in some.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13778","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T23:24:15Z","timestamp":1623194655000},"page":"327-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long\u2010term prognosis: A retrospective cohort study"],"prefix":"10.1002","volume":"157","author":[{"given":"Ping","family":"An","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xirong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases  Shanghai China"},{"name":"Institute of Biomedical Sciences of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6765-459X","authenticated-orcid":false,"given":"Yu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80078-6"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"221","article-title":"Congenital adenomatoid malformation of one lobe of a lung with general anasarca","volume":"48","author":"Ch'In KY","year":"1949","journal-title":"Arch Pathol. 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