{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:52:12Z","timestamp":1774381932650,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The fetal risks and benefits of antihypertensives to treat gestational hypertension in pregnancy are understudied, particularly in low\u2010 and middle\u2010income countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a nested case\u2010control study within a retrospective cohort of obstetrical patients in Botswana from 2014 to 2019. We included women carrying singletons who developed new onset non\u2010severe hypertension (140\u2013159\u00a0mm\u00a0Hg systolic or 90\u2013109\u00a0mm\u00a0Hg diastolic blood pressure) after 20\u00a0weeks of pregnancy. Cases were defined as women with either small\u2010for\u2010gestational\u2010age (SGA) infants or stillbirth, analyzed separately; controls were otherwise similar women without the adverse outcome in each analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 1932 cases of SGA (7925 controls) and 316 cases of stillbirth (9619 controls). Cases with SGA were more likely to have used an anti\u2010hypertensive than controls (33% vs 29%, adjusted odds ratio [aOR] 1.28, 95% confidence interval [CI] 1.15\u20131.43). Cases with stillbirth were more likely to have used an anti\u2010hypertensive than controls (42% versus 29%, aOR 1.45, 95% CI 1.14\u20131.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010hypertensive use for new\u2010onset gestational hypertension was associated with an increased risk of having an SGA infant or a stillbirth among women who never developed severe hypertension. These data support conduct of a randomized clinical trial to determine the appropriate use of anti\u2010hypertensives in non\u2010severe gestational hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13809","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T07:25:09Z","timestamp":1625210709000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010hypertensive use for non\u2010severe gestational hypertension in Botswana: A case\u2010control study"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-8139","authenticated-orcid":false,"given":"Katherine M.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Zash","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Modest","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Luckett","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Modiegi","family":"Diseko","sequence":"additional","affiliation":[{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mompati","family":"Mmalane","sequence":"additional","affiliation":[{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Makhema","sequence":"additional","affiliation":[{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Ramogola\u2010Masire","sequence":"additional","affiliation":[{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine, University of Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair J.","family":"Wylie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston MA USA"},{"name":"Botswana\u2010Harvard Partnership  Gaborone Botswana"},{"name":"Department of Immunology and Infectious Diseases Harvard T.H. 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