{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:03:08Z","timestamp":1791644588149,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate improvement of stress urinary incontinence (SUI) and functional status of the urethra after autologous skeletal\u2010muscle derived cell (aSMDC) implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phase I\u2013II, open, non\u2010randomized, single\u2010center study of ultrasound guided aSMDC implantation (dosed at 0.2\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\u00a0cells\/2\u00a0mL) into the external urethral sphincter to treat SUI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 patients were treated and followed for 2\u00a0years. SUI measured by Incontinence Episode Frequency score, short pad test, quality of life, patient's and clinician's perception significantly improved and remained improved after 2\u00a0years. However, urodynamic urethral properties in general did not improve at 1\u2010year after treatment. Subgroup analysis revealed that addition of an adjuvant functional electrical stimulation therapy discontinued 4\u00a0weeks after injection in the compliant group, gave better urodynamic values and maintained the long\u2010term SUI improvement at 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The aSMDC injection was safe and well\u2010tolerated by patients. The status of SUI improved and with it the quality of life of patients, even if this was not necessarily reflected in the urodynamic urethral properties. Electrical stimulation, as an adjuvant therapy, could have an essential role in the success of the therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical registration<\/jats:title><jats:p>Clinical study was registered under Eudra\u2010CT number: 2010\u2010021867\u201034 at European Clinical Trial Database (EudraCT), accessible at: EudraCT (europa.eu).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13853","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T07:55:04Z","timestamp":1628236504000},"page":"444-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The effect of skeletal muscle\u2010derived cells implantation on stress urinary incontinence and functional urethral properties in female patients"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2581","authenticated-orcid":false,"given":"Mija","family":"Blaganje","sequence":"first","affiliation":[{"name":"Department of Gynecology Division of Obstetrics and Gynecology University Medical Center Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"Lukanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Gynecology Division of Obstetrics and Gynecology University Medical Center Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02243-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-007-0475-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.01.082"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.07.026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2007.07119.x"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"307","article-title":"Autologous muscle\u2010derived cells as therapy for stress urinary incontinence: a randomized blinded trial","volume":"29","author":"Herschorn S","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1255-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1963-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.11.029"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22404"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00679-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-002-1004-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.035"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.03.040"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000007783465118"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0114"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-016-0411-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.06.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099123"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930100503"},{"key":"e_1_2_8_22_1","first-page":"75","article-title":"Pelvic Organ Prolapse Quantification System (POPO\u2010Q) \u2013 a new era in pelvic prolapse staging","volume":"4","author":"Persu C","year":"2011","journal-title":"J Med Life"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920200018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00004025"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1679-45082010ao1611"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10047"},{"issue":"3","key":"e_1_2_8_27_1","first-page":"153","article-title":"Correlation between clinical presentation and urodynamic findings in women attending urogynecology clinic","volume":"4","author":"Pandey D","year":"2013","journal-title":"J Midlife Health"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.028"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.02.047"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-018-2005-8"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.01.002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-56847-6_3"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00510.2014"}],"container-title":["International Journal of Gynecology &amp; 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