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Recurrence needs to be prevented since the prognosis for recurrent endometrial cancer is dismal. Treatment tailored to tumor biology is the optimal strategy to balance treatment efficacy against toxicity. Since The Cancer Genome Atlas defined four molecular subgroups of endometrial cancers, the molecular factors are increasingly used to define prognosis and treatment. Standard treatment consists of hysterectomy and bilateral salpingo\u2010oophorectomy. Lymphadenectomy (and increasingly sentinel node biopsy) enables identification of lymph node\u2010positive patients who need adjuvant treatment, including radiotherapy and chemotherapy. Adjuvant therapy is used for Stage I\u2013II patients with high\u2010risk factors and Stage III patients; chemotherapy is especially used in non\u2010endometrioid cancers and those in the copy\u2010number high molecular group characterized by\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation. 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