{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:46:47Z","timestamp":1793094407258,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To revise the FIGO staging for carcinoma of the vulva using a new approach that involves analyses of prospectively collected data. The FIGO Committee for Gynecologic Oncology reviewed the recent literature to gain an insight into the impact of the 2009 vulvar cancer staging revision. The Committee resolved to revise the staging with a goal of simplification and actively collaborated with the United States National Cancer Database to analyze prospectively collected data on carcinoma of the vulva. Many tumor characteristics were collected for all stages of vulvar cancer treated between 2010 and 2017. Statistical analysis was performed with SAS software. Overall survival was estimated based on tumor characteristics. Log\u2010rank and Wilcoxon tests were used to analyze overall survival similarities between and within groups of tumor characteristics. Characteristics with similar survivals were then grouped into the same stages and substages. Kaplan\u2013Meier overall survival curves were generated for the resulting stages and substages. There were 12\u00a0063 cases with available data. The resulting new staging for carcinoma of the vulva has two substages in Stage\u00a0I, no substage in Stage\u00a0II, three substages in Stage\u00a0III, and two substages in Stage\u00a0IV. The Kaplan\u2013Meier overall survival curves showed clear separation between stages and substages. The 2021 vulvar cancer staging is the first from the FIGO Committee for Gynecologic Oncology to be derived from data analyses. This revision has a new definition for depth of invasion, uses the same definition for lymph node metastases utilized in cervical cancer, and allows findings from cross\u2010sectional imaging to be incorporated into vulvar cancer staging. The 2021 FIGO staging for carcinoma of the vulva is data\u2010derived, validated, and much simpler than earlier revisions.<\/jats:p>","DOI":"10.1002\/ijgo.13880","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:25:16Z","timestamp":1631611516000},"page":"43-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["FIGO staging for carcinoma of the vulva: 2021 revision"],"prefix":"10.1002","volume":"155","author":[{"given":"Alexander B.","family":"Olawaiye","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cotler","sequence":"additional","affiliation":[{"name":"National Cancer Database American College of Surgeons Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio A.","family":"Cuello","sequence":"additional","affiliation":[{"name":"Department of Gynecology Division of Obstetrics and Gynecology School of Medicine Pontificia Universidad Cat\u00f3lica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerja","family":"Bhatla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikou","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarikapan","family":"Wilailak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittaranjan N.","family":"Purandare","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Purandare Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Lindeque","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Pretoria Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Berek","sequence":"additional","affiliation":[{"name":"Stanford Women\u2019s Cancer Center Stanford Cancer Institute Stanford University School of Medicine Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Oxford Gynecological Cancer Center Churchill Hospital Oxford UK"},{"name":"St Peter\u2019s College Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70137-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.06.033"},{"key":"e_1_2_9_5_1","first-page":"927","article-title":"Comparison of clinical versus surgical staging systems in vulvar cancer","volume":"80","author":"Shanbour KA","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.06.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2683-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.08.036"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000544"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12749"},{"key":"e_1_2_9_14_1","first-page":"419","volume-title":"Female Genital Tumours. 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