{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:53Z","timestamp":1747149293348,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare outcomes in higher\u2010order multiple pregnancies reduced to dichorionic diamniotic (DCDA) twins with primary DCDA twins and singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study included all higher\u2010order multiple pregnancies that underwent ultrasound\u2010guided transabdominal fetal reduction at 11\u201313\u00a0weeks of gestation from January 2018 to June 2020. Outcomes were compared with 100 primary DCDA twins and 1078\u00a0singletons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four higher\u2010order multiples underwent reduction at mean gestational age of 11.46\u00a0weeks. Of the reduced pregnancies, 3.12% resulted in miscarriage before 24\u00a0weeks compared with 2% (2\/100) of primary twins and 0.74% of singletons (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09). The mean gestational age at delivery was 33.48\u00a0weeks for reduced twins, 34.52\u00a0weeks for primary twins (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.10) and 38.14\u00a0weeks for singletons (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Compared with primary twins, the adjusted odds of preterm delivery before 34\u00a0weeks and before 36\u00a0weeks for reduced twins were 0.56 (95% confidence interval [CI] 0.48\u20133.54, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.62) and 0.84 (95% CI 0.78\u20138.85, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08), respectively. There was no significant difference in rates of pre\u2010eclampsia, Cesarean delivery, birth weight below the 10th and 3rd centiles, and perinatal mortality among primary and reduced twins. All risks were significantly lower in singleton pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced twins have similar obstetric and perinatal outcomes as primary twins, but adverse outcomes are significantly higher in both groups when compared with singleton pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13901","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T18:54:13Z","timestamp":1630349653000},"page":"671-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical outcomes in higher\u2010order multiples reduced to dichorionic diamniotic (DCDA) twins compared with primary twins and singletons: A prospective observational study"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-8481","authenticated-orcid":false,"given":"Chanchal","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine Madhukar Rainbow Children\u2019s Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Fetal Medicine Madhukar Rainbow Children\u2019s Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazala","family":"Shahnaz","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Madhukar Rainbow Children\u2019s Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savita","family":"Dagar","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Madhukar Rainbow Children\u2019s Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditi","family":"Shastri","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Madhukar Rainbow Children\u2019s Hospital  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeksha","family":"Khurana","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health Public Health Foundation of India  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"e158\u201363","article-title":"Multifetal pregnancy reduction. 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