{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:56:27Z","timestamp":1773316587933,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019871","name":"Beijing Obstetrics and Gynecology Hospital, Capital Medical University","doi-asserted-by":"publisher","award":["fcyy201613"],"award-info":[{"award-number":["fcyy201613"]}],"id":[{"id":"10.13039\/501100019871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the changes of uterine leiomyoma size during pregnancy and determine the factors influencing it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted from June 2016 to June 2018. Women with pregnancies complicated by leiomyoma were recruited. Ultrasound examinations were conducted to measure the size of leiomyoma during 6\u20137, 11\u201314, 22\u201324, 28\u201334\u00a0weeks of pregnancy and before delivery. The clinical characteristics and delivery details of the pregnant women were collected. Changes in leiomyoma size during different gestation periods and the influencing factors were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leiomyoma size commonly increased before 22\u201324\u00a0weeks of pregnancy and the fastest growth occurred before 11\u201314\u00a0weeks. From 22\u201324\u00a0weeks to the date of delivery, the size of leiomyoma remained unchanged. The initial size of the leiomyoma showed negative correlation with the changes in leiomyoma diameters during pregnancy. Pre\u2010pregnancy body mass index, fetus number, leiomyoma location, and parity were positively correlated with the size changes in leiomyoma from 22\u201324 to 28\u201334\u00a0weeks of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Before 22\u201324\u00a0weeks of pregnancy, the size of the leiomyoma was gestation\u2010dependent, which increases with gestational weeks. The fastest growth rate was before 11\u201314\u00a0weeks. The growth of leiomyoma is affected by multiple factors, and different factors can play different roles during different periods of the pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.13903","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T19:09:35Z","timestamp":1630091375000},"page":"677-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study"],"prefix":"10.1002","volume":"157","author":[{"given":"Yu\u2010cui","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Perinatal Medicine Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Service Taizhou Blood Center  Taizhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Perinatal Medicine Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-5137","authenticated-orcid":false,"given":"Yin\u2010mei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gynecology Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing Maternal and Child Health Care Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-4007-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8826"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.01.032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2020.1846020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.2019.0058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2019.01.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186078"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010019\u20100795\u20101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2006.04.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.035"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4621-4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22704"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.018"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.12891\/ceog2024.2016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15677"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2298\/SARH1402118S"},{"key":"e_1_2_8_19_1","first-page":"453","article-title":"Sonographic assessment of pregnancy co\u2010existing with uterine leiomyoma in Owerri, Nigeria","volume":"13","author":"Eze CU","year":"2013","journal-title":"Afr Health Sci"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.11.008"},{"key":"e_1_2_8_22_1","first-page":"313","article-title":"The place of selective progesterone receptor modulators in myoma therapy","volume":"68","author":"Donnez J","year":"2016","journal-title":"Minerva Ginecol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-019-0803-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EDE.0000054360.61254.27"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.093"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18092014"}],"container-title":["International Journal of Gynecology &amp; 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