{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:17Z","timestamp":1786977857872,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy of the injection of microfragmented adipose tissue in the treatment of women with genitourinary syndrome of menopause (GSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This observational cohort study included 12 women who received one session of multiple injections of microfragmented adipose tissue using the SEFFIGYN\n                      <jats:sup>\u2122<\/jats:sup>\n                      medical device. Symptoms such as burning, itching, dryness, pain on penetration, pain during deep intercourse, and pain on urination were assessed before the patient's treatment (T0), after 15\u00a0days (T15), and after 5\u00a0months (5Mo) using the Numerical Rating Scale (NRS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An improvement of vulvar trophism was clinically evident already 2\u00a0weeks after treatment; all symptoms were notably attenuated compared with the initial visit, as demonstrated by statistically significant reductions of the NRS scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003 for itching,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.008 for pain on urination, and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 for the other symptoms, Sign test). Moreover, all symptoms continued to improve over time. All patients reported a positive change in their quality of life and a resumption of sexual life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of microfragmented adipose tissue in GSM is promising. Nevertheless, more studies will be fundamental to exclude a potential placebo effect and better understand the underlying molecular mechanism of action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.13906","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T05:04:21Z","timestamp":1630386261000},"page":"536-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A new approach to regenerative medicine in gynecology"],"prefix":"10.1002","volume":"157","author":[{"given":"Marina","family":"Mantovani","sequence":"first","affiliation":[{"name":"CHECK\u2010UP Center Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-725X","authenticated-orcid":false,"given":"Alessandro","family":"Gennai","sequence":"additional","affiliation":[{"name":"Plastic Reconstructive and Aesthetic Surgeon Medical Director STUDIO GENNAI Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Rosalba","family":"Russo","sequence":"additional","affiliation":[{"name":"Estemed Aesthetic Clinic Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21200"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00857.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108765"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.24279"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.02.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i8.454"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.10.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjv001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw084"},{"issue":"1","key":"e_1_2_7_11_1","article-title":"Superficial enhanced fluid fat injection (SEFFI and MicroSEFFI) in facial rejuvenation","volume":"5","author":"Gennai A","year":"2017","journal-title":"CellR4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.12970\/2310-998X.2020.08.05"},{"issue":"2","key":"e_1_2_7_13_1","article-title":"Safety and efficacy of stromal vascular fraction enriched fat grafting therapy for vulvar lichen sclerosus","volume":"12","author":"Monreal J","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"2561461","DOI":"10.1155\/2016\/2561461","article-title":"The use of human adipose\u2010derived stem cells in the treatment of physiological and pathological vulval dystrophies","volume":"2016","author":"Onesti MG","year":"2016","journal-title":"Stem Cells Int"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12686"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjx056"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55100615"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2018.0008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.12.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1677-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000401"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.07.007"},{"key":"e_1_2_7_23_1","first-page":"1","article-title":"Biorevitalization of postmenopausal labia majora, the polynucleotide\/hyaluronic acid option","volume":"3","author":"Palmieri P","year":"2019","journal-title":"Obstet Gynecol Rep"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2015.04.004"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurox.2019.100037"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2840-y"}],"updated-by":[{"DOI":"10.1002\/ijgo.15471","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000}}],"container-title":["International Journal of Gynecology &amp; 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